CHST12

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.[5][6]

CHST12
Identifiers
Aliases	CHST12, C4S-2, C4ST-2, C4ST2, carbohydrate (chondroitin 4) sulfotransferase 12, carbohydrate sulfotransferase 12
External IDs	OMIM: 610129 MGI: 1929064 HomoloGene: 69258 GeneCards: CHST12
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 2,403,588 bp[1] End 2,448,484 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 140,505,550 bp[2] End 140,525,724 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • sulfotransferase activity • 3'-phosphoadenosine 5'-phosphosulfate binding • chondroitin 4-sulfotransferase activity Cellular component • integral component of membrane • integral component of Golgi membrane • Golgi membrane • Golgi apparatus • membrane Biological process • chondroitin sulfate biosynthetic process • dermatan sulfate biosynthetic process • carbohydrate biosynthetic process • carbohydrate metabolic process • proteoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55501	59031
Ensembl	ENSG00000136213	ENSMUSG00000036599
UniProt	Q9NRB3	Q99LL3
RefSeq (mRNA)	NM_001243794 NM_001243795 NM_018641	NM_021528
RefSeq (protein)	NP_001230723 NP_001230724 NP_061111	NP_067503
Location (UCSC)	Chr 7: 2.4 – 2.45 Mb	Chr 5: 140.51 – 140.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136213 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036599 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (Aug 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". J Biol Chem. 275 (26): 20188–96. doi:10.1074/jbc.M002443200. PMID 10781601.
6. "Entrez Gene: CHST12 carbohydrate (chondroitin 4) sulfotransferase 12".

External links

• Human CHST12 genome location and CHST12 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Mikami T, Mizumoto S, Kago N, et al. (2003). "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis". J. Biol. Chem. 278 (38): 36115–27. doi:10.1074/jbc.M306044200. PMID 12847091.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.