CHMP6

Charged multivesicular body protein 6 is a protein that in humans is encoded by the CHMP6 gene.[5][6][7]

CHMP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K3W, 3HTU
Identifiers
Aliases	CHMP6, VPS20, charged multivesicular body protein 6
External IDs	OMIM: 610901 MGI: 3583942 HomoloGene: 11607 GeneCards: CHMP6
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 80,991,598 bp[1] End 81,009,517 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 119,913,441 bp[2] End 119,919,548 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein N-terminus binding • GO:0001948 protein binding • GO:0032403 macromolecular complex binding Cellular component • ESCRT III complex • cytosol • endosome • membrane • late endosome membrane • endosome membrane • extracellular exosome • endomembrane system Biological process • GO:0019067 viral life cycle • nucleus organization • regulation of exosomal secretion • multivesicular body assembly • ESCRT III complex assembly • endosomal transport • protein transport • cell separation after cytokinesis • mitotic metaphase plate congression • vacuolar transport • macroautophagy • negative regulation of epidermal growth factor-activated receptor activity • transport • regulation of protein catabolic process • midbody abscission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79643	208092
Ensembl	ENSG00000176108	ENSMUSG00000025371
UniProt	Q96FZ7	P0C0A3
RefSeq (mRNA)	NM_024591	NM_001085498
RefSeq (protein)	NP_078867	NP_001078967
Location (UCSC)	Chr 17: 80.99 – 81.01 Mb	Chr 11: 119.91 – 119.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000176108 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025371 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. PMID 11559748.
6. Yorikawa C, Shibata H, Waguri S, Hatta K, Horii M, Katoh K, Kobayashi T, Uchiyama Y, Maki M (Mar 2005). "Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting". Biochem J. 387 (Pt 1): 17–26. doi:10.1042/BJ20041227. PMC 1134928. PMID 15511219.
7. "Entrez Gene: CHMP6 chromatin modifying protein 6".

External links

• Human CHMP6 genome location and CHMP6 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.