CFLAR

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.[5][6] Also called c-FLIP (FLICE-like inhibitory protein).

CFLAR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H11, 3H13, 2N5R
Identifiers
Aliases	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP
External IDs	OMIM: 603599 MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 201,116,154 bp[1] End 201,176,687 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C1.3|1 29.16 cM Start 58,711,508 bp[2] End 58,758,884 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cysteine-type peptidase activity • GO:0001948 protein binding • cysteine-type endopeptidase activity involved in execution phase of apoptosis • GO:0010577 enzyme activator activity • cysteine-type endopeptidase activity • peptidase activator activity • protein heterodimerization activity • protease binding • death receptor binding • GO:0032403 macromolecular complex binding • cysteine-type endopeptidase activity involved in apoptotic process Cellular component • cytosol • CD95 death-inducing signaling complex • ripoptosome • death-inducing signaling complex • membrane raft • cytoplasm Biological process • regulation of apoptotic process • execution phase of apoptosis • negative regulation of apoptotic process • proteolysis • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of necroptotic process • regulation of extrinsic apoptotic signaling pathway via death domain receptors • GO:0022415 viral process • apoptotic process • GO:0048554 positive regulation of catalytic activity • response to hypoxia • negative regulation of cardiac muscle cell apoptotic process • positive regulation of neuron projection development • cellular response to insulin stimulus • response to testosterone • positive regulation of ERK1 and ERK2 cascade • cellular response to epidermal growth factor stimulus • cellular response to estradiol stimulus • cellular response to hypoxia • cellular response to dexamethasone stimulus • cellular response to nitric oxide • positive regulation of glomerular mesangial cell proliferation • positive regulation of extracellular matrix organization • negative regulation of reactive oxygen species biosynthetic process • negative regulation of cellular response to transforming growth factor beta stimulus • negative regulation of hepatocyte apoptotic process • negative regulation of epithelial cell apoptotic process • positive regulation of hepatocyte proliferation • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • skeletal muscle tissue development • positive regulation of peptidase activity • skeletal muscle atrophy • regulation of skeletal muscle satellite cell proliferation • skeletal myofibril assembly • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • skeletal muscle tissue regeneration • positive regulation of NF-kappaB transcription factor activity • negative regulation of necroptotic process • negative regulation of myoblast fusion • negative regulation of extrinsic apoptotic signaling pathway • response to bacterium Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8837	12633
Ensembl	ENSG00000003402	ENSMUSG00000026031
UniProt	O15519	O35732
RefSeq (mRNA)	NM_001127183 NM_001127184 NM_001202515 NM_001202516 NM_001202517 NM_001202518 NM_001202519 NM_001308042 NM_001308043 NM_003879 NM_001351590 NM_001351591 NM_001351592 NM_001351593 NM_001351594	NM_001289704 NM_001293804 NM_001293805 NM_009805 NM_207653 NM_001355056
RefSeq (protein)	NP_001120655 NP_001120656 NP_001189444 NP_001189445 NP_001189446 NP_001189447 NP_001189448 NP_001294971 NP_001294972 NP_003870 NP_001338519 NP_001338520 NP_001338521 NP_001338522 NP_001338523	NP_001276633 NP_001280733 NP_001280734 NP_033935 NP_997536 NP_001341985
Location (UCSC)	Chr 2: 201.12 – 201.18 Mb	Chr 1: 58.71 – 58.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000003402 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026031 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
6. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP" (PDF). Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161.

Further reading

• Abe K, Kurakin A, Mohseni-Maybodi M, et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand". Ann. N. Y. Acad. Sci. 926 (1): 52–63. doi:10.1111/j.1749-6632.2000.tb05598.x. PMID 11193041.
• Dutton A, Young LS, Murray PG (2006). "The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer". Expert Opin. Ther. Targets. 10 (1): 27–35. doi:10.1517/14728222.10.1.27. PMID 16441226.

External links

• Human CFLAR genome location and CFLAR gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O15519 (CASP8 and FADD-like apoptosis regulator) at the PDBe-KB.