CFHR4

Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene.[3][4][5]

CFHR4
Identifiers
Aliases	CFHR4, CFHL4, FHR-4, FHR4, complement factor H related 4
External IDs	OMIM: 605337 HomoloGene: 136449 GeneCards: CFHR4
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.3 Start 196,888,014 bp[1] End 196,918,713 bp[1]
Gene ontology Molecular function • lipid transporter activity Cellular component • extracellular region Biological process • lipid transport • regulation of complement activation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10877	n/a
Ensembl	ENSG00000134365	n/a
UniProt	Q92496	n/a
RefSeq (mRNA)	NM_001201550 NM_001201551 NM_006684	n/a
RefSeq (protein)	NP_001188479 NP_001188480 NP_006675	n/a
Location (UCSC)	Chr 1: 196.89 – 196.92 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000134365 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Skerka C, Hellwage J, Weber W, Tilkorn A, Buck F, Marti T, Kampen E, Beisiegel U, Zipfel PF (Apr 1997). "The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins". J Biol Chem. 272 (9): 5627–34. doi:10.1074/jbc.272.9.5627. PMID 9038172.
4. Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D (Jul 1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701.
5. "Entrez Gene: CFHR4 complement factor H-related 4".

Further reading

• Hageman GS, Hancox LS, Taiber AJ, et al. (2007). "Extended Haplotypes in the Complement Factor H (CFH) and CFH-related (CFHR) Family of Genes that Protect against Age-related Macular Degeneration: Identification, Ethnic Distribution and Evolutionary Implications". Ann. Med. 38 (8): 592–604. doi:10.1080/07853890601097030. PMC 1905836. PMID 17438673.
• Józsi M, Richter H, Löschmann I, et al. (2005). "FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene". Eur. J. Hum. Genet. 13 (3): 321–9. doi:10.1038/sj.ejhg.5201324. PMID 15562282.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hellwage J, Jokiranta TS, Koistinen V, et al. (2000). "Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin". FEBS Lett. 462 (3): 345–52. doi:10.1016/S0014-5793(99)01554-9. PMID 10622723.
• Hellwage J, Skerka C, Zipfel PF (1998). "Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4)". Immunopharmacology. 38 (1–2): 149–57. doi:10.1016/S0162-3109(97)00075-1. PMID 9476126.

External links

• GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
• OMIM entries on Atypical Hemolytic-Uremic Syndrome
• Human CFHR4 genome location and CFHR4 gene details page in the UCSC Genome Browser.