CFHR2

Complement factor H-related protein 2 is a protein that in humans is encoded by the CFHR2 gene.[3][4][5]

CFHR2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3ZD1, 5EA0
Identifiers
Aliases	CFHR2, CFHL2, FHR2, HFL3, complement factor H related 2
External IDs	OMIM: 600889 HomoloGene: 130536 GeneCards: CFHR2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.3 Start 196,943,738 bp[1] End 196,959,622 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein homodimerization activity • protein heterodimerization activity Cellular component • extracellular region • macromolecular complex Biological process • regulation of complement activation • negative regulation of protein binding • positive regulation of cytolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3080	n/a
Ensembl	ENSG00000080910	n/a
UniProt	P36980	n/a
RefSeq (mRNA)	NM_001312672 NM_005666	n/a
RefSeq (protein)	NP_001299601 NP_005657	n/a
Location (UCSC)	Chr 1: 196.94 – 196.96 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000080910 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Skerka C, Timmann C, Horstmann RD, Zipfel PF (Jun 1992). "Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes". J Immunol. 148 (10): 3313–8. PMID 1533657.
4. Skerka C, Moulds JM, Taillon-Miller P, Hourcade D, Zipfel PF (Oct 1995). "The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene". Immunogenetics. 42 (4): 268–74. doi:10.1007/bf00176444. PMID 7672821.
5. "Entrez Gene: CFHR2 complement factor H-related 2".

External links

• Human CFHR2 genome location and CFHR2 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P36980 (Complement factor H-related protein 2) at the PDBe-KB.

Further reading

• Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?". Immunol. Today. 15 (3): 121–6. doi:10.1016/0167-5699(94)90155-4. PMID 8172644.
• Hageman GS, Hancox LS, Taiber AJ, et al. (2007). "Extended Haplotypes in the Complement Factor H (CFH) and CFH-related (CFHR) Family of Genes that Protect against Age-related Macular Degeneration: Identification, Ethnic Distribution and Evolutionary Implications". Ann. Med. 38 (8): 592–604. doi:10.1080/07853890601097030. PMC 1905836. PMID 17438673.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D (1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701.
• Skerka C, Horstmann RD, Zipfel PF (1991). "Molecular cloning of a human serum protein structurally related to complement factor H". J. Biol. Chem. 266 (18): 12015–20. PMID 1711047.