CENTG3

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 is an enzyme that in humans is encoded by the AGAP3 gene.[5]

AGAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IHW
Identifiers
Aliases	AGAP3, AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
External IDs	OMIM: 616813 MGI: 2183446 HomoloGene: 23742 GeneCards: AGAP3
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.1 Start 151,085,831 bp[1] End 151,144,436 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 24,452,177 bp[2] End 24,502,047 bp[2]
Gene ontology Molecular function • nucleotide binding • GTP binding • metal ion binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GTPase activity • polyubiquitin modification-dependent protein binding Cellular component • membrane • cell nucleus • cytoplasm • cell periphery Biological process • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • signal transduction • cellular response to reactive oxygen species • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116988	213990
Ensembl	ENSG00000133612	ENSMUSG00000023353
UniProt	Q96P47 Q86ST5	Q8VHH5
RefSeq (mRNA)	NM_001042535 NM_001281300 NM_001308304 NM_001308305 NM_031946 NM_001350102 NM_001350103 NM_001350104	NM_001256431 NM_139153 NM_001359881
RefSeq (protein)	NP_001036000 NP_001268229 NP_001295233 NP_001295234 NP_114152 NP_001337031 NP_001337032 NP_001337033 NP_001036000.1 NP_001295233.1 NP_001295234.1	n/a
Location (UCSC)	Chr 7: 151.09 – 151.14 Mb	Chr 5: 24.45 – 24.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000133612 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023353 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CENTG3 centaurin, gamma 3".

External links

• Human AGAP3 genome location and AGAP3 gene details page in the UCSC Genome Browser.

Further reading

• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243.
• Qin Q, Inatome R, Hotta A, et al. (2006). "A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein". J. Cell Biol. 172 (4): 497–504. doi:10.1083/jcb.200505079. PMC 2063670. PMID 16461359.
• Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–49354. doi:10.1074/jbc.M410565200. PMID 15381706.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484–51493. doi:10.1074/jbc.M305622200. PMID 14506264.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Xia C, Ma W, Stafford LJ, et al. (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476–2488. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.