CELA2A

Chymotrypsin-like elastase family member 2A is an enzyme that in humans is encoded by the CELA2A gene.[5][6][7]

CELA2A
Identifiers
Aliases	CELA2A, ELA2A, PE-1, chymotrypsin like elastase family member 2A, chymotrypsin like elastase 2A, AOMS4
External IDs	OMIM: 609443 MGI: 95316 HomoloGene: 40598 GeneCards: CELA2A
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.21 Start 15,456,728 bp[1] End 15,472,091 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E1|4 74.75 cM Start 141,814,962 bp[2] End 141,826,160 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • serine hydrolase activity • peptidase activity • serine-type peptidase activity • hydrolase activity • endopeptidase activity • serine-type endopeptidase activity Cellular component • keratohyalin granule • extracellular region • extracellular • cytosol Biological process • proteolysis • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63036	13706
Ensembl	ENSG00000142615	ENSMUSG00000058579
UniProt	P08217	P05208
RefSeq (mRNA)	NM_033440	NM_007919
RefSeq (protein)	NP_254275	NP_031945
Location (UCSC)	Chr 1: 15.46 – 15.47 Mb	Chr 4: 141.81 – 141.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000142615 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058579 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kawashima I, Tani T, Shimoda K, Takiguchi Y (Jul 1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2): 163–72. doi:10.1089/dna.1987.6.163. PMID 3646943.
6. Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al. (Jun 1988). "Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2". J Biochem. 102 (6): 1555–63. PMID 2834346.
7. "Entrez Gene: ELA2A elastase 2A".

External links

• Human CELA2A genome location and CELA2A gene details page in the UCSC Genome Browser.

Further reading

• Moulard M, Michon T, Kerfelec B, Chapus C (1990). "Further studies on the human pancreatic binary complexes involving procarboxypeptidase A." FEBS Lett. 261 (1): 179–83. doi:10.1016/0014-5793(90)80665-6. PMID 2307232.
• Fletcher TS, Shen WF, Largman C (1988). "Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA". Biochemistry. 26 (23): 7256–61. doi:10.1021/bi00397a010. PMID 3427074.
• Friess H, Ding J, Kleeff J, et al. (2002). "Identification of disease-specific genes in chronic pancreatitis using DNA array technology". Ann. Surg. 234 (6): 769–78, discussion 778–9. doi:10.1097/00000658-200112000-00008. PMC 1422136. PMID 11729383.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lausen J, Liu S, Fliegauf M, et al. (2006). "ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO". Oncogene. 25 (9): 1349–57. doi:10.1038/sj.onc.1209181. PMID 16247445.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.