CCAAT/enhancer binding protein zeta

CCAAT/enhancer-binding protein zeta is a protein that in humans is encoded by the CEBPZ gene.[5][6][7]

CEBPZ
Identifiers
Aliases	CEBPZ, CBF, CBF2, HSP-CBF, NOC1, CCAAT/enhancer binding protein zeta, CCAAT enhancer binding protein zeta
External IDs	OMIM: 612828 MGI: 109386 HomoloGene: 4210 GeneCards: CEBPZ
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.2 Start 37,201,612 bp[1] End 37,231,596 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E3 Start 78,919,006 bp[2] End 78,937,066 bp[2]
Gene ontology Molecular function • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • RNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • ribosome biogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10153	12607
Ensembl	ENSG00000115816	ENSMUSG00000024081
UniProt	Q03701	P53569
RefSeq (mRNA)	NM_005760	NM_001024806 NM_009882
RefSeq (protein)	NP_005751	NP_001019977
Location (UCSC)	Chr 2: 37.2 – 37.23 Mb	Chr 17: 78.92 – 78.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CCAAT/enhancer binding protein zeta has been shown to interact with:

• NFYB,[8]
• P53,[6]
• P73[9]

See also

• Ccaat-enhancer-binding proteins

References

1. GRCh38: Ensembl release 89: ENSG00000115816 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024081 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lum LS, Sultzman LA, Kaufman RJ, Linzer DI, Wu BJ (Jan 1991). "A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter". Mol Cell Biol. 10 (12): 6709–17. PMC 362949. PMID 2247079.
6. Uramoto H, Izumi H, Nagatani G, Ohmori H, Nagasue N, Ise T, Yoshida T, Yasumoto K, Kohno K (Apr 2003). "Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression". Biochem J. 371 (Pt 2): 301–10. doi:10.1042/BJ20021646. PMC 1223307. PMID 12534345.
7. "Entrez Gene: CEBPZ CCAAT/enhancer binding protein zeta".
8. Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9. doi:10.1074/jbc.M101553200. PMID 11306579.
9. Uramoto H, Izumi H, Nagatani G, Ohmori H, Nagasue N, Ise T, Yoshida T, Yasumoto K, Kohno K (Apr 2003). "Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression". Biochem. J. 371 (Pt 2): 301–10. doi:10.1042/BJ20021646. PMC 1223307. PMID 12534345.

Further reading

• Hoeppner MA, Gilbert DJ, Copeland NG, Jenkins NA, Linzer DI, Wu B (1996). "Cloning and characterization of mouse CCAAT binding factor". Nucleic Acids Res. 24 (6): 1091–8. doi:10.1093/nar/24.6.1091. PMC 145757. PMID 8604343.
• Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R (2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9. doi:10.1074/jbc.M101553200. PMID 11306579.
• Iouzalen N, Andreae S, Hannier S, Triebel F (2001). "LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway". Eur. J. Immunol. 31 (10): 2885–91. doi:10.1002/1521-4141(2001010)31:10<2885::AID-IMMU2885>3.0.CO;2-2. PMID 11592063.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Milkereit P, Strauss D, Bassler J, Gadal O, Kühn H, Schütz S, Gas N, Lechner J, Hurt E, Tschochner H (2003). "A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits". J. Biol. Chem. 278 (6): 4072–81. doi:10.1074/jbc.M208898200. PMID 12446671.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• CEBPz+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• CEBPZ human gene location in the UCSC Genome Browser.
• CEBPZ human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.