CDCA8

Borealin is a protein that in humans is encoded by the CDCA8 gene.[5][6][7]

CDCA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KDD, 2QFA, 2RAW, 2RAX
Identifiers
Aliases	CDCA8, BOR, BOREALIN, DasraB, MESRGP, cell division cycle associated 8
External IDs	OMIM: 609977 MGI: 1196274 HomoloGene: 23075 GeneCards: CDCA8
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,692,481 bp[1] End 37,709,719 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 57.93 cM Start 124,918,465 bp[2] End 124,939,311 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • intercellular bridge • nucleolus • nucleoplasm • cytoplasm • spindle • chromosome • cytosol • cell nucleus • chromosome, centromeric region • chromocenter • midbody • chromosome passenger complex • spindle midzone • cytoskeleton • macromolecular complex Biological process • chromosome organization • cell cycle • cell division • mitotic metaphase plate congression • mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55143	52276
Ensembl	ENSG00000134690	ENSMUSG00000028873
UniProt	Q53HL2	Q8BHX3
RefSeq (mRNA)	NM_018101 NM_001256875	NM_026560
RefSeq (protein)	NP_001243804 NP_060571	NP_080836
Location (UCSC)	Chr 1: 37.69 – 37.71 Mb	Chr 4: 124.92 – 124.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[7][8]

Interactions

CDCA8 has been shown to interact with INCENP,[8] Survivin[6][8] and Aurora B kinase.[6][8]

References

1. GRCh38: Ensembl release 89: ENSG00000134690 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028873 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
6. Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.
7. "Entrez Gene: CDCA8 cell division cycle associated 8".
8. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH (Jan 2005). "Proteome analysis of the human mitotic spindle". Molecular & Cellular Proteomics. 4 (1): 35–43. doi:10.1074/mcp.M400158-MCP200. PMID 15561729.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Vader G, Kauw JJ, Medema RH, Lens SM (Jan 2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody". EMBO Reports. 7 (1): 85–92. doi:10.1038/sj.embor.7400562. PMC 1369225. PMID 16239925.
• Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P, Wheatley SP (Jan 2006). "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis". The Journal of Biological Chemistry. 281 (2): 1286–95. doi:10.1074/jbc.M508773200. PMID 16291752.
• Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM (Apr 2006). "Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer". Experimental Cell Research. 312 (7): 962–73. doi:10.1016/j.yexcr.2005.12.015. PMID 16427043.
• Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH (Apr 2006). "Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres". Molecular Biology of the Cell. 17 (4): 1897–909. doi:10.1091/mbc.E05-08-0727. PMC 1415303. PMID 16436504.
• Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G (Aug 2006). "Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown". Oncogene. 25 (35): 4867–79. doi:10.1038/sj.onc.1209499. PMID 16547492.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Klein UR, Nigg EA, Gruneberg U (Jun 2006). "Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP". Molecular Biology of the Cell. 17 (6): 2547–58. doi:10.1091/mbc.E05-12-1133. PMC 1474794. PMID 16571674.
• Kaur H, Stiff AC, Date DA, Taylor WR (2007). "Analysis of mitotic phosphorylation of borealin". BMC Cell Biology. 8: 5. doi:10.1186/1471-2121-8-5. PMC 1794407. PMID 17241471.
• Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y (May 2007). "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis". Cancer Research. 67 (9): 4113–22. doi:10.1158/0008-5472.CAN-06-4705. PMID 17483322.

External links

• Human CDCA8 genome location and CDCA8 gene details page in the UCSC Genome Browser.