CDCA5

Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.[8]

Clinical significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation.[9]

gollark: You can actually *click* the name of a peripheral and it's automagically put on your clipboard.
gollark: So, if you rightclick a modem, it tells you the name of peripherals on it, yes?
gollark: Also, minor but probably important QoL thing: please make it so that you can click the license key to copy it to clipboards like you can with peripheral names.
gollark: It's more a thing of random BIOS additions and making compatibility with potatOS more annoying.
gollark: I like the websocket chatbox idea, but please don't add the event conversion thing as yet another background coroutine.

References
  1. GRCh38: Ensembl release 89: ENSG00000146670 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024791 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
  6. Rankin S, Ayad NG, Kirschner MW (Apr 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
  7. "Entrez Gene: CDCA5 cell division cycle associated 5".
  8. Schmitz, J.; Watrin, E.; Lénárt, P.; Mechtler, K.; Peters, JM. (Apr 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Curr Biol. 17 (7): 630–6. doi:10.1016/j.cub.2007.02.029. hdl:21.11116/0000-0002-101C-D. PMID 17349791.
  9. Nguyen, MH.; Koinuma, J.; Ueda, K.; Ito, T.; Tsuchiya, E.; Nakamura, Y.; Daigo, Y. (Jul 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis". Cancer Res. 70 (13): 5337–47. doi:10.1158/0008-5472.CAN-09-4372. PMID 20551060.

Further reading


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