CDCA5

CDCA5
Identifiers
Aliases	CDCA5, SORORIN, cell division cycle associated 5
External IDs	OMIM: 609374 MGI: 1915099 HomoloGene: 49860 GeneCards: CDCA5
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	65,084,164 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	6,091,777 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• chromatin binding; • GO:0001948 protein binding; • GO:0032403 macromolecular complex binding;
Cellular component	• cytoplasm; • cytosol; • cohesin complex; • chromosome; • nucleoplasm; • nuclear chromatin; • chromatin; • chromosome, centromeric region; • cell nucleus;
Biological process	• mitotic chromosome condensation; • positive regulation of exit from mitosis; • regulation of cohesin loading; • cell division; • mitotic sister chromatid cohesion; • double-strand break repair; • cell cycle; • mitotic metaphase plate congression; • GO:0007067 mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	113130
	67849
	ENSG00000146670
	ENSMUSG00000024791
	Q96FF9
	Q9CPY3
	NM_080668
	NM_026410
	NP_542399
	NP_080686
	Wikidata
View/Edit Human	View/Edit Mouse

Sororin is a protein that in humans is encoded by the CDCA5 gene.[5][6][7]

Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.[8]

Clinical significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation.[9]

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References

GRCh38: Ensembl release 89: ENSG00000146670 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024791 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
Rankin S, Ayad NG, Kirschner MW (Apr 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
"Entrez Gene: CDCA5 cell division cycle associated 5".
Schmitz, J.; Watrin, E.; Lénárt, P.; Mechtler, K.; Peters, JM. (Apr 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Curr Biol. 17 (7): 630–6. doi:10.1016/j.cub.2007.02.029. hdl:21.11116/0000-0002-101C-D. PMID 17349791.
Nguyen, MH.; Koinuma, J.; Ueda, K.; Ito, T.; Tsuchiya, E.; Nakamura, Y.; Daigo, Y. (Jul 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis". Cancer Res. 70 (13): 5337–47. doi:10.1158/0008-5472.CAN-09-4372. PMID 20551060.

External links

Human CDCA5 genome location and CDCA5 gene details page in the UCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Schmitz J, Watrin E, Lénárt P, et al. (2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Curr. Biol. 17 (7): 630–6. doi:10.1016/j.cub.2007.02.029. hdl:21.11116/0000-0002-101C-D. PMID 17349791.
Díaz-Martínez LA, Giménez-Abián JF, Clarke DJ (2007). "Regulation of centromeric cohesion by sororin independently of the APC/C". Cell Cycle. 6 (6): 714–24. doi:10.4161/cc.6.6.3935. PMID 17361102.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146670 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024791 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12188893-5] Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.

[pmid15837422-6] Rankin S, Ayad NG, Kirschner MW (Apr 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.

[entrez-7] "Entrez Gene: CDCA5 cell division cycle associated 5".

[Schmitz-2007-8] Schmitz, J.; Watrin, E.; Lénárt, P.; Mechtler, K.; Peters, JM. (Apr 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Curr Biol. 17 (7): 630–6. doi:10.1016/j.cub.2007.02.029. hdl:21.11116/0000-0002-101C-D. PMID 17349791.

[Nguyen-2010-9] Nguyen, MH.; Koinuma, J.; Ueda, K.; Ito, T.; Tsuchiya, E.; Nakamura, Y.; Daigo, Y. (Jul 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis". Cancer Res. 70 (13): 5337–47. doi:10.1158/0008-5472.CAN-09-4372. PMID 20551060.

CDCA5

Function

Clinical significance

References

External links

Further reading