CDCA3

Cell division cycle-associated protein 3 is a protein that in humans is encoded by the CDCA3 gene.[5][6][7]

CDCA3
Identifiers
Aliases	CDCA3, GRCC8, TOME-1, cell division cycle associated 3
External IDs	OMIM: 607749 MGI: 1315198 HomoloGene: 8403 GeneCards: CDCA3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,844,793 bp[1] End 6,852,066 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.17 cM Start 124,829,547 bp[2] End 124,833,701 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytosol • cytoplasm Biological process • cell division • cell cycle • protein ubiquitination • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83461	14793
Ensembl	ENSG00000111665	ENSMUSG00000023505
UniProt	Q99618	Q99M54
RefSeq (mRNA)	NM_001297602 NM_001297603 NM_001297604 NM_031299 NM_001331019	NM_013538
RefSeq (protein)	NP_001284531 NP_001284532 NP_001284533 NP_001317948 NP_112589	NP_038566
Location (UCSC)	Chr 12: 6.84 – 6.85 Mb	Chr 6: 124.83 – 124.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CDCA3 has been shown to interact with SKP1A.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000111665 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023505 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (May 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
6. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
7. "Entrez Gene: CDCA3 cell division cycle associated 3".
8. Ayad, Nagi G; Rankin Susannah; Murakami Monica; Jebanathirajah Judith; Gygi Steven; Kirschner Marc W (Apr 2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. United States. 113 (1): 101–13. doi:10.1016/S0092-8674(03)00232-0. ISSN 0092-8674. PMID 12679038.

External links

• Human CDCA3 genome location and CDCA3 gene details page in the UCSC Genome Browser.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Yoshida K (2005). "Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters". FEBS Lett. 579 (6): 1488–92. doi:10.1016/j.febslet.2005.01.055. PMID 15733861.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ayad NG, Rankin S, Murakami M, et al. (2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. 113 (1): 101–13. doi:10.1016/S0092-8674(03)00232-0. PMID 12679038.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.