CD300C

CMRF35-like molecule 6 (CLM-6) also known as CD300 antigen-like family member C (CD300c) is a protein that in humans is encoded by the CD300C gene.[5][6][7]

CD300C
Identifiers
Aliases	CD300C, CLM-6, CMRF-35, CMRF-35A, CMRF35, CMRF35-A1, CMRF35A, CMRF35A1, IGSF16, LIR, CD300c molecule
External IDs	OMIM: 606786 MGI: 2153249 HomoloGene: 74580 GeneCards: CD300C
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 74,541,073 bp[1] End 74,546,115 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E2|11 80.57 cM Start 114,996,721 bp[2] End 115,001,880 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transmembrane signaling receptor activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • cellular defense response • immune system process • regulation of immune response • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10871	140497
Ensembl	ENSG00000167850	ENSMUSG00000044811
UniProt	Q08708	Q7TSN2
RefSeq (mRNA)	NM_006678	NM_134158
RefSeq (protein)	NP_006669	NP_598919
Location (UCSC)	Chr 17: 74.54 – 74.55 Mb	Chr 11: 115 – 115 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000167850 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044811 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jackson DG, Hart DN, Starling G, Bell JI (Jun 1992). "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor". Eur J Immunol. 22 (5): 1157–63. doi:10.1002/eji.1830220508. PMID 1349532.
6. Clark GJ, Green BJ, Hart DN (Aug 2000). "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17". Tissue Antigens. 55 (2): 101–9. doi:10.1034/j.1399-0039.2000.550201.x. PMID 10746781.
7. "Entrez Gene: CD300C CD300c molecule".

External links

• Human CD300C genome location and CD300C gene details page in the UCSC Genome Browser.

Further reading

• Clark GJ, Fitzpatrick S, Kuo B, Modra C, Jamriska L, Hart DN (2002). "CMRF-35A, CMRF-35H: potential new CD". J. Biol. Regul. Homeost. Agents. 16 (3): 233–5. PMID 12456026.
• Cannon JP, Haire RN, Litman GW (December 2002). "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate". Nat. Immunol. 3 (12): 1200–7. doi:10.1038/ni849. PMID 12415263.
• Clark GJ, Cooper B, Fitzpatrick S, Green BJ, Hart DN (May 2001). "The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family". Tissue Antigens. 57 (5): 415–23. doi:10.1034/j.1399-0039.2001.057005415.x. PMID 11556966.