CCNL1

Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.[5][6]

CCNL1
Identifiers
Aliases	CCNL1, ANIA6A, PRO1073, ania-6a, BM-001, cyclin L1
External IDs	OMIM: 613384 MGI: 1922664 HomoloGene: 10541 GeneCards: CCNL1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.31 Start 157,146,508 bp[1] End 157,160,760 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E1 Start 65,946,151 bp[2] End 65,958,249 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cyclin-dependent protein serine/threonine kinase regulator activity • GO:0001948 protein binding Cellular component • nuclear speck • cyclin-dependent protein kinase holoenzyme complex • nucleoplasm • cell nucleus Biological process • positive regulation of phosphorylation of RNA polymerase II C-terminal domain • RNA processing • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57018	56706
Ensembl	ENSG00000163660	ENSMUSG00000027829
UniProt	Q9UK58	Q52KE7
RefSeq (mRNA)	NM_001308185 NM_020307	NM_001025442 NM_001025443 NM_019937 NM_001355432 NM_001355433
RefSeq (protein)	NP_001295114 NP_064703	NP_064321 NP_001342361 NP_001342362
Location (UCSC)	Chr 3: 157.15 – 157.16 Mb	Chr 3: 65.95 – 65.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000163660 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027829 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (Jul 2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". J Biol Chem. 277 (28): 25465–73. doi:10.1074/jbc.M202266200. PMID 11980906.
6. "Entrez Gene: CCNL1 cyclin L1".

External links

• Human CCNL1 genome location and CCNL1 gene details page in the UCSC Genome Browser.

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Berke JD, Sgambato V, Zhu PP, et al. (2001). "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin". Neuron. 32 (2): 277–87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997.
• Redon R, Hussenet T, Bour G, et al. (2002). "Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer". Cancer Res. 62 (21): 6211–7. PMID 12414649.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sticht C, Hofele C, Flechtenmacher C, et al. (2005). "Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)". Br. J. Cancer. 92 (4): 770–4. doi:10.1038/sj.bjc.6602400. PMC 2361871. PMID 15700036.
• Muller D, Millon R, Théobald S, et al. (2006). "Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma". Br. J. Cancer. 94 (7): 1041–4. doi:10.1038/sj.bjc.6603036. PMC 2361229. PMID 16598186.