CCAR1

Cell division cycle and apoptosis regulator protein 1 is a protein that in humans is encoded by the CCAR1 gene.[5][6]

CCAR1
Identifiers
Aliases	CCAR1, cell division cycle and apoptosis regulator 1
External IDs	OMIM: 612569 MGI: 1914750 HomoloGene: 10086 GeneCards: CCAR1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q21.3 Start 68,721,012 bp[1] End 68,792,377 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 62,743,928 bp[2] End 62,792,286 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • GO:0001106 transcription corepressor activity • ligand-dependent nuclear receptor transcription coactivator activity • GO:0001105 transcription coactivator activity • RNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component • cytoplasm • perinuclear region of cytoplasm • nucleoplasm • cell nucleus Biological process • positive regulation of cell migration • mRNA splicing, via spliceosome • cell cycle • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of cell proliferation • apoptotic process • negative regulation of nucleic acid-templated transcription • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55749	67500
Ensembl	ENSG00000060339	ENSMUSG00000020074
UniProt	Q8IX12	Q8CH18
RefSeq (mRNA)	NM_001282959 NM_001282960 NM_018237	NM_026201
RefSeq (protein)	NP_001269888 NP_001269889 NP_060707	NP_080477
Location (UCSC)	Chr 10: 68.72 – 68.79 Mb	Chr 10: 62.74 – 62.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000060339 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020074 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rishi AK, Zhang L, Boyanapalli M, Wali A, Mohammad RM, Yu Y, Fontana JA, Hatfield JS, Dawson MI, Majumdar AP, Reichert U (Aug 2003). "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437". J Biol Chem. 278 (35): 33422–35. doi:10.1074/jbc.M303173200. PMID 12816952.
6. "Entrez Gene: CCAR1 cell division cycle and apoptosis regulator 1".

External links

• Human CCAR1 genome location and CCAR1 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6170–5. doi:10.1073/pnas.0307459101. PMC 395941. PMID 15069192.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rishi AK, Zhang L, Yu Y, et al. (2006). "Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor". J. Biol. Chem. 281 (19): 13188–98. doi:10.1074/jbc.M512279200. PMID 16543231.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Zhang L, Levi E, Majumder P, et al. (2007). "Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo". Mol. Cancer Ther. 6 (5): 1661–72. doi:10.1158/1535-7163.MCT-06-0653. PMID 17513614.