Caspase recruitment domain-containing protein 8

Caspase recruitment domain-containing protein 8 is a protein that in humans is encoded by the CARD8 gene.[3][4][5]

CARD8
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4IKM
Identifiers
Aliases	CARD8, CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN, caspase recruitment domain family member 8
External IDs	OMIM: 609051 HomoloGene: 136365 GeneCards: CARD8
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,180,770 bp[1] End 48,255,946 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cysteine-type endopeptidase activator activity involved in apoptotic process • GO:0001948 protein binding • protein homodimerization activity • NACHT domain binding • CARD domain binding • identical protein binding Cellular component • NLRP3 inflammasome complex • nucleoplasm • cytoplasm • cell nucleus • cytosol • macromolecular complex • inflammasome Biological process • apoptotic process • regulation of apoptotic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of interleukin-1 beta secretion • negative regulation of I-kappaB kinase/NF-kappaB signaling • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of tumor necrosis factor-mediated signaling pathway • negative regulation of lipopolysaccharide-mediated signaling pathway • negative regulation of NF-kappaB transcription factor activity • negative regulation of interleukin-1 beta secretion • inhibition of cysteine-type endopeptidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22900	n/a
Ensembl	ENSG00000105483	n/a
UniProt	Q9Y2G2	n/a
RefSeq (mRNA)	NM_001184900 NM_001184901 NM_001184902 NM_001184903 NM_001184904 NM_014959 NM_001351782 NM_001351783 NM_001351784 NM_001351786 NM_001351787 NM_001351788 NM_001351789 NM_001351790 NM_001351791 NM_001351792 NM_001365950	n/a
RefSeq (protein)	NP_001171829 NP_001171830 NP_001171831 NP_001171832 NP_001171833 NP_055774 NP_001338711 NP_001338712 NP_001338713 NP_001338715 NP_001338716 NP_001338717 NP_001338718 NP_001338719 NP_001338720 NP_001338721 NP_001352879	n/a
Location (UCSC)	Chr 19: 48.18 – 48.26 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NF-κB) in the context of apoptosis or inflammation, respectively.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000105483 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
4. Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, Torii S, Kitada S, Krajewski S, Welsh K, Pio F, Godzik A, Reed JC (Aug 2001). "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer". J Biol Chem. 276 (34): 32220–9. doi:10.1074/jbc.M100433200. PMID 11408476.
5. "Entrez Gene: CARD8 caspase recruitment domain family, member 8".

Further reading

• Fontalba A, Martinez-Taboada V, Gutierrez O, et al. (2007). "Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity". J. Immunol. 179 (7): 4867–73. doi:10.4049/jimmunol.179.7.4867. PMID 17878386.
• Franke A, Rosenstiel P, Balschun T, et al. (2007). "No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample". Gastroenterology. 132 (5): 2080–1. doi:10.1053/j.gastro.2007.03.087. PMID 17484912.
• McGovern DP, Butler H, Ahmad T, et al. (2006). "TUCAN (CARD8) genetic variants and inflammatory bowel disease". Gastroenterology. 131 (4): 1190–6. doi:10.1053/j.gastro.2006.08.008. PMID 17030188.
• Checinska A, Giaccone G, Hoogeland BS, et al. (2006). "TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells". BMC Cancer. 6: 166. doi:10.1186/1471-2407-6-166. PMC 1538619. PMID 16796750.
• Agostini L, Martinon F, Burns K, et al. (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder". Immunity. 20 (3): 319–25. doi:10.1016/S1074-7613(04)00046-9. PMID 15030775.
• Stilo R, Leonardi A, Formisano L, et al. (2002). "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation". FEBS Lett. 521 (1–3): 165–9. doi:10.1016/S0014-5793(02)02869-7. PMID 12067710.
• Zhang H, Fu W (2002). "NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation". Int. J. Oncol. 20 (5): 1035–40. doi:10.3892/ijo.20.5.1035. PMID 11956601.
• Razmara M, Srinivasula SM, Wang L, et al. (2002). "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis". J. Biol. Chem. 277 (16): 13952–8. doi:10.1074/jbc.M107811200. PMID 11821383.
• Bouchier-Hayes L, Conroy H, Egan H, et al. (2001). "CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways". J. Biol. Chem. 276 (47): 44069–77. doi:10.1074/jbc.M107373200. PMID 11551959.