CABYR

Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.[5][6][7][8]

CABYR
Identifiers
Aliases	CABYR, CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2, calcium binding tyrosine phosphorylation regulated
External IDs	OMIM: 612135 MGI: 1918382 HomoloGene: 49299 GeneCards: CABYR
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 24,138,956 bp[1] End 24,161,603 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 12,740,322 bp[2] End 12,755,260 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • enzyme binding • calcium ion binding • GO:0001948 protein binding • protein domain specific binding • metal ion binding • protein heterodimerization activity Cellular component • cytoplasm • sperm principal piece • cell projection • motile cilium • cilium • sperm fibrous sheath • cytoskeleton • cell nucleus • sperm end piece • cytosol • extracellular region Biological process • sperm capacitation • epithelial cilium movement Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26256	71132
Ensembl	ENSG00000154040	ENSMUSG00000024430
UniProt	O75952	Q9D424
RefSeq (mRNA)	NM_001308231 NM_012189 NM_138643 NM_138644 NM_153768 NM_153769 NM_153770	NM_001042418 NM_001042419 NM_001042420 NM_027687 NM_181731
RefSeq (protein)	NP_001295160 NP_036321 NP_619584 NP_619585 NP_722452 NP_722453 NP_722454 NP_001295160.1	NP_001035883 NP_001035884 NP_001035885 NP_081963 NP_859420
Location (UCSC)	Chr 18: 24.14 – 24.16 Mb	Chr 18: 12.74 – 12.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000154040 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024430 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC (Jan 2002). "CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation". Dev Biol. 242 (2): 236–54. doi:10.1006/dbio.2001.0527. PMID 11820818.
6. Luo C, Xiao X, Liu D, Chen S, Li M, Xu A, Liu J, Gao S, Wu S, He D (Feb 2007). "CABYR is a novel cancer-testis antigen in lung cancer". Clin Cancer Res. 13 (4): 1288–97. doi:10.1158/1078-0432.CCR-06-1742. PMID 17317841.
7. Kim YH, Jha KN, Mandal A, Vanage G, Farris E, Snow PL, Klotz K, Naaby-Hansen S, Flickinger CJ, Herr JC (Oct 2005). "Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A". Dev Biol. 286 (1): 46–56. doi:10.1016/j.ydbio.2005.07.005. PMID 16139264.
8. "Entrez Gene: CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)".

External links

• Human CABYR genome location and CABYR gene details page in the UCSC Genome Browser.

Further reading

• Fouquet JP, Kann ML (1995). "The cytoskeleton of mammalian spermatozoa". Biol. Cell. 81 (2): 89–93. doi:10.1016/S0248-4900(94)80001-4. PMID 7849610.
• Visconti PE, Westbrook VA, Chertihin O, et al. (2002). "Novel signaling pathways involved in sperm acquisition of fertilizing capacity". J. Reprod. Immunol. 53 (1–2): 133–50. doi:10.1016/S0165-0378(01)00103-6. PMID 11730911.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ficarro S, Chertihin O, Westbrook VA, et al. (2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". J. Biol. Chem. 278 (13): 11579–89. doi:10.1074/jbc.M202325200. PMID 12509440.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hsu HC, Lee YL, Cheng TS, et al. (2005). "Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain". Biochem. Biophys. Res. Commun. 329 (3): 1108–17. doi:10.1016/j.bbrc.2005.02.089. PMID 15752768.