CAB39

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.[5]

CAB39
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UPK, 1UPL, 2WTK, 3GNI, 4FZA, 4FZD, 4FZF, 4NZW, 4O27
Identifiers
Aliases	CAB39, MO25, CGI-66, calcium binding protein 39
External IDs	OMIM: 612174 MGI: 107438 HomoloGene: 69212 GeneCards: CAB39
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 230,712,842 bp[1] End 230,821,075 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 85,793,441 bp[2] End 85,851,576 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein serine/threonine kinase activator activity • protein kinase activator activity • protein serine/threonine kinase activity • kinase binding • GO:0001948 protein binding Cellular component • cytoplasm • cytosol • serine/threonine protein kinase complex • extracellular exosome • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen • macromolecular complex Biological process • GO:0007243 intracellular signal transduction • protein heterooligomerization • signal transduction by protein phosphorylation • cellular hypotonic response • positive regulation of protein serine/threonine kinase activity • negative regulation of potassium ion transmembrane transporter activity • positive regulation of peptidyl-threonine phosphorylation • peptidyl-serine phosphorylation • cell cycle arrest • negative regulation of potassium ion transmembrane transport • activation of protein kinase activity • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51719	12283
Ensembl	ENSG00000135932	ENSMUSG00000036707
UniProt	Q9Y376	Q06138
RefSeq (mRNA)	NM_001130849 NM_001130850 NM_016289	NM_133781 NM_001355046 NM_001355047
RefSeq (protein)	NP_001124321 NP_001124322 NP_057373	NP_598542 NP_001341975 NP_001341976
Location (UCSC)	Chr 2: 230.71 – 230.82 Mb	Chr 1: 85.79 – 85.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene associates with STK11 (Serine/Threonine Kinase 11) and STRAD (STE20-Related ADaptor protein).[6] CAB39 enhances formation of STK11/STRAD complexes and stimulates STK11 catalytic activity. CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000135932 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036707 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CAB39 calcium binding protein 39".
6. Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (October 2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473. PMID 14517248.

External links

• Human CAB39 genome location and CAB39 gene details page in the UCSC Genome Browser.

Further reading

• Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312–9. doi:10.1016/j.tcb.2004.04.001. PMID 15183188.
• Hawley SA, Davison M, Woods A, et al. (1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase". J. Biol. Chem. 271 (44): 27879–87. doi:10.1074/jbc.271.44.27879. PMID 8910387.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Boudeau J, Baas AF, Deak M, et al. (2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473. PMID 14517248.
• Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
• Milburn CC, Boudeau J, Deak M, et al. (2004). "Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor". Nat. Struct. Mol. Biol. 11 (2): 193–200. doi:10.1038/nsmb716. PMID 14730349.
• Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Boudeau J, Scott JW, Resta N, et al. (2005). "Analysis of the LKB1-STRAD-MO25 complex". J. Cell Sci. 117 (Pt 26): 6365–75. doi:10.1242/jcs.01571. PMID 15561763.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.