BTG4

Protein BTG4 also known as BTG family member 4 is a protein that in humans is encoded by the BTG4 gene (B-cell translocation gene 4).[5][6] BTG4 has anti-proliferative properties and can induce G₁ cell cycle arrest.[6]

BTG4
Identifiers
Aliases	BTG4, PC3B, BTG family member 4, BTG anti-proliferation factor 4, APRO3
External IDs	OMIM: 605673 MGI: 1860140 HomoloGene: 9734 GeneCards: BTG4
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.1 Start 111,467,526 bp[1] End 111,512,354 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 51,060,901 bp[2] End 51,119,875 bp[2]
Orthologs
Species	Human	Mouse
Entrez	54766	56057
Ensembl	ENSG00000137707	ENSMUSG00000032056
UniProt	Q9NY30	O70552
RefSeq (mRNA)	NM_017589 NM_001367974 NM_001367975 NM_001367976	NM_019493
RefSeq (protein)	NP_060059 NP_001354903 NP_001354904 NP_001354905	NP_062366
Location (UCSC)	Chr 11: 111.47 – 111.51 Mb	Chr 9: 51.06 – 51.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000137707 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032056 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: B-cell translocation gene 4".
6. Buanne P, Corrente G, Micheli L, Palena A, Lavia P, Spadafora C, Lakshmana MK, Rinaldi A, Banfi S, Quarto M, Bulfone A, Tirone F (September 2000). "Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium". Genomics. 68 (3): 253–63. doi:10.1006/geno.2000.6288. PMID 10995567.

External links

• Human BTG4 genome location and BTG4 gene details page in the UCSC Genome Browser.

Further reading

• Auer RL, Starczynski J, McElwaine S, et al. (2005). "Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia". Genes Chromosomes Cancer. 43 (1): 1–10. doi:10.1002/gcc.20159. PMID 15672409.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dong W, Tu S, Xie J, et al. (2009). "Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer". Biochem. Biophys. Res. Commun. 387 (1): 132–8. doi:10.1016/j.bbrc.2009.06.140. PMID 19576178.
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC 5926753. PMID 11429045.
• Toyota M, Suzuki H, Sasaki Y, et al. (2008). "Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer". Cancer Res. 68 (11): 4123–32. doi:10.1158/0008-5472.CAN-08-0325. PMID 18519671.
• Tirone F (2001). "The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?". J. Cell. Physiol. 187 (2): 155–65. doi:10.1002/jcp.1062. PMID 11267995.