BTBD1

BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the BTBD1 gene.[5]

BTBD1
Identifiers
AliasesBTBD1, C15orf1, NS5ATP8, BTB domain containing 1
External IDsOMIM: 608530 MGI: 1933765 HomoloGene: 23529 GeneCards: BTBD1
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q25.2Start83,016,423 bp[1]
End83,067,252 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

53339

83962

Ensembl

ENSG00000064726

ENSMUSG00000025103

UniProt

Q9H0C5

P58544

RefSeq (mRNA)

NM_001011885
NM_025238

NM_146193

RefSeq (protein)

NP_001011885
NP_079514

NP_666305

Location (UCSC)Chr 15: 83.02 – 83.07 MbChr 7: 81.79 – 81.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

Interactions

BTBD1 has been shown to interact with TOP1.[6]

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References

  1. GRCh38: Ensembl release 89: ENSG00000064726 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025103 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: BTBD1 BTB (POZ) domain containing 1".
  6. Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.

Further reading


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