CUGBP Elav-like family member 4

CUGBP Elav-like family member 4 (CELF4) also known as bruno-like protein 4 (BRUNOL4) is a protein that in humans is encoded by the CELF4 gene.[4][5]

CELF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DGP, 2DNK
Identifiers
Aliases	CELF4, BRUNOL-4, BRUNOL4, CELF-4, CUGBP, Elav-like family member 4, CUGBP Elav-like family member 4
External IDs	OMIM: 612679 MGI: 1932407 HomoloGene: 23202 GeneCards: CELF4
Gene location (Mouse) Chr. Chromosome 18 (mouse)[1] Band 18|18 A2 Start 25,477,632 bp[1] End 25,754,157 bp[1]
Gene ontology Molecular function • RNA binding • BRE binding • mRNA binding • nucleic acid binding • translation repressor activity, nucleic acid binding • pre-mRNA binding Cellular component • cytoplasm • cell nucleus • ribonucleoprotein Biological process • germ cell development • mRNA processing • negative regulation of mRNA splicing, via spliceosome • alternative mRNA splicing, via spliceosome • mRNA splice site selection • regulation of alternative mRNA splicing, via spliceosome • negative regulation of excitatory postsynaptic potential • RNA splicing • positive regulation of mRNA splicing, via spliceosome • negative regulation of translation • regulation of retina development in camera-type eye • embryo development ending in birth or egg hatching Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56853	108013
Ensembl	n/a	ENSMUSG00000024268
UniProt	Q9BZC1	Q7TSY6
RefSeq (mRNA)	NM_001025087 NM_001025088 NM_001025089 NM_020180 NM_001330603	NM_001146292 NM_001146293 NM_001146294 NM_001146295 NM_001174074 NM_133195
RefSeq (protein)	NP_001020258 NP_001020259 NP_001020260 NP_001317532 NP_064565 NP_001340624 NP_001340625 NP_001340626 NP_001340627 NP_001340628 NP_001340629 NP_001340630 NP_001340631 NP_001340632 NP_001340634 NP_001340635 NP_001340637 NP_001340638 NP_001340639 NP_001340640 NP_001340641 NP_001340642 NP_001340643 NP_001340644 NP_001340645 NP_001340646 NP_001340647 NP_001340648 NP_001340649 NP_001340650 NP_001340651 NP_001340652 NP_001340653 NP_001340654 NP_001340655 NP_001340656 NP_001340657 NP_001340658 NP_001340659 NP_001340660 NP_001340661 NP_001340662 NP_001340663 NP_001340664 NP_001340665 NP_001340666 NP_001340667 NP_001340668 NP_001340669 NP_001340670 NP_001340671 NP_001340672 NP_001340673 NP_001340674 NP_001340675 NP_001340676 NP_001340677 NP_001340678 NP_001340679 NP_001340680 NP_001340681 NP_001340682 NP_001340683 NP_001340684 NP_001340685 NP_001340686 NP_001340687 NP_001340688 NP_001340689 NP_001340690 NP_001340636	NP_001139764 NP_001139765 NP_001139766 NP_001167545 NP_573458 NP_001349204 NP_001349205 NP_001349206 NP_001349207 NP_001349208 NP_001349209 NP_001349210 NP_001349211 NP_001349212 NP_001349213 NP_001349214 NP_001349215 NP_001349217 NP_001349218 NP_001349219 NP_001349220 NP_001349221 NP_001349222 NP_001349223 NP_001349224 NP_001349226 NP_001349228 NP_001349229 NP_001349230 NP_001349231 NP_001349232 NP_001349237 NP_001349238 NP_001349239 NP_001349240 NP_001349242 NP_001349244 NP_001349245 NP_001349252 NP_001349253 NP_001349254 NP_001349255 NP_001349256 NP_001349257 NP_001349258 NP_001349259 NP_001349260 NP_001349261 NP_001349263 NP_001349264 NP_001349265 NP_001349266 NP_001349233 NP_001349251
Location (UCSC)	n/a	Chr 18: 25.48 – 25.75 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000024268 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Good PJ, Chen Q, Warner SJ, Herring DC (Oct 2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator". J Biol Chem. 275 (37): 28583–92. doi:10.1074/jbc.M003083200. PMID 10893231.
5. "Entrez Gene: BRUNOL4 bruno-like 4, RNA binding protein (Drosophila)".

External links

• Human CELF4 genome location and CELF4 gene details page in the UCSC Genome Browser.

Further reading

• Szafranski K, Schindler S, Taudien S, et al. (2008). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
• Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMC 1126903. PMID 15894795.
• Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMC 373409. PMID 14973222.
• Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
• Ladd AN, Charlet N, Cooper TA (2001). "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMC 99581. PMID 11158314.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.