BRMS1

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.[5][6]

BRMS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRMS1, breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator
External IDsOMIM: 606259 MGI: 2388804 HomoloGene: 32260 GeneCards: BRMS1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.2Start66,337,333 bp[1]
End66,345,125 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25855

107392

Ensembl

ENSG00000174744

ENSMUSG00000080268

UniProt

Q9HCU9

Q99N20

RefSeq (mRNA)

NM_015399
NM_001024957
NM_001024958

NM_134155
NM_001374047
NM_001374048

RefSeq (protein)

NP_001020128
NP_056214

NP_598916
NP_001360976
NP_001360977

Location (UCSC)Chr 11: 66.34 – 66.35 MbChr 19: 5.04 – 5.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[7] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000174744 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000080268 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Research. 60 (11): 2764–9. PMID 10850410.
  6. "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
  7. Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

Further reading


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