BRK1

BRICK1 is a putative micropeptide protein that in humans is encoded by the C3orf10 gene.[5][6]

BRK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P8C, 4N78
Identifiers
Aliases	BRK1, C3orf10, MDS027, hHBrk1, HSPC300, BRICK1, SCAR/WAVE actin nucleating complex subunit, BRICK1 subunit of SCAR/WAVE actin nucleating complex
External IDs	OMIM: 611183 MGI: 1915406 HomoloGene: 10210 GeneCards: BRK1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 10,115,675 bp[1] End 10,127,190 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E3 Start 113,604,772 bp[2] End 113,616,951 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rac GTPase binding • GO:0001948 protein binding • GO:0032403 macromolecular complex binding • identical protein binding Cellular component • cytoplasm • cytosol • extracellular exosome • cytoskeleton • SCAR complex • lamellipodium Biological process • vascular endothelial growth factor receptor signaling pathway • Rac protein signal transduction • positive regulation of Arp2/3 complex-mediated actin nucleation • in utero embryonic development • positive regulation of lamellipodium assembly • actin cytoskeleton organization • Fc-gamma receptor signaling pathway involved in phagocytosis • positive regulation of cell proliferation • protein homotrimerization • actin filament organization • cell motility • regulation of actin polymerization or depolymerization • positive regulation of protein complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55845	101314
Ensembl	ENSG00000254999	ENSMUSG00000033940
UniProt	Q8WUW1	Q91VR8
RefSeq (mRNA)	NM_018462	NM_133937
RefSeq (protein)	NP_060932	NP_598698
Location (UCSC)	Chr 3: 10.12 – 10.13 Mb	Chr 6: 113.6 – 113.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000254999 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033940 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maranchie JK, Afonso A, Albert PS, Kalyandrug S, Phillips JL, Zhou S, Peterson J, Ghadimi BM, Hurley K, Riss J, Vasselli JR, Ried T, Zbar B, Choyke P, Walther MM, Klausner RD, Linehan WM (Jan 2004). "Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location". Human Mutation. 23 (1): 40–6. doi:10.1002/humu.10302. PMID 14695531.
6. "Entrez Gene: C3orf10 chromosome 3 open reading frame 10".

Further reading

• Cascón A, Escobar B, Montero-Conde C, Rodríguez-Antona C, Ruiz-Llorente S, Osorio A, Mercadillo F, Letón R, Campos JM, García-Sagredo JM, Benítez J, Malumbres M, Robledo M (Jun 2007). "Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients". Human Mutation. 28 (6): 613–21. doi:10.1002/humu.20496. PMID 17311301.
• Mayne M, Moffatt T, Kong H, McLaren PJ, Fowke KR, Becker KG, Namaka M, Schenck A, Bardoni B, Bernstein CN, Melanson M (Apr 2004). "CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion". European Journal of Immunology. 34 (4): 1217–27. doi:10.1002/eji.200324726. PMID 15048733.
• Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature. 418 (6899): 790–3. doi:10.1038/nature00859. PMID 12181570.
• Witke W, Podtelejnikov AV, Di Nardo A, Sutherland JD, Gurniak CB, Dotti C, Mann M (Feb 1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly". The EMBO Journal. 17 (4): 967–76. doi:10.1093/emboj/17.4.967. PMC 1170446. PMID 9463375.
• Kitamura T, Kitamura Y, Yonezawa K, Totty NF, Gout I, Hara K, Waterfield MD, Sakaue M, Ogawa W, Kasuga M (Feb 1996). "Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck". Biochemical and Biophysical Research Communications. 219 (2): 509–14. doi:10.1006/bbrc.1996.0264. PMID 8605018.

External links

• Human BRK1 genome location and BRK1 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein BRICK1