BRD7

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.[5][6][7]

BRD7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRD7, BP75, CELTIX1, NAG4, bromodomain containing 7
External IDsOMIM: 618489 MGI: 1349766 HomoloGene: 8085 GeneCards: BRD7
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q12.1Start50,313,487 bp[1]
End50,368,934 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

29117

26992

Ensembl

ENSG00000166164

ENSMUSG00000031660

UniProt

Q9NPI1

O88665

RefSeq (mRNA)

NM_001173984
NM_013263

NM_012047

RefSeq (protein)

NP_001167455
NP_037395

Location (UCSC)Chr 16: 50.31 – 50.37 MbChr 8: 88.33 – 88.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

BRD7 has been shown to interact with IRF2[8] and HNRPUL1.[9]

Azoospermia

BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced.[10] Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.[10]

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References

  1. GRCh38: Ensembl release 89: ENSG00000166164 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031660 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W (November 1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein". FEBS Lett. 459 (3): 291–298. doi:10.1016/S0014-5793(99)01191-6. PMID 10526152.
  6. Kaeser MD, Aslanian A, Dong MQ, Yates JR III, Emerson BM (November 2008). "BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells". J Biol Chem. 283 (47): 32254–32263. doi:10.1074/jbc.M806061200. PMC 2583284. PMID 18809673.
  7. "Entrez Gene: BRD7 bromodomain containing 7".
  8. Staal, A; Enserink J M; Stein J L; Stein G S; van Wijnen A J (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. UNITED STATES. 185 (2): 269–279. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. ISSN 0021-9541. PMID 11025449.
  9. Kzhyshkowska, Julia; Rusch Andre; Wolf Hans; Dobner Thomas (April 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. England. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. ISSN 0264-6021. PMC 1223277. PMID 12489984.
  10. Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, Liu Y, Fan L, Xiong W, Ma J, Peng S, Zeng Z, Zhou Y, Li X, Li Z, Li X, Schmitt DC, Tan M, Li G, Zhou M (2016). "Knockout of BRD7 results in impaired spermatogenesis and male infertility". Sci Rep. 6: 21776. Bibcode:2016NatSR...621776W. doi:10.1038/srep21776. PMC 4754950. PMID 26878912.

Further reading

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