BPI fold-containing family B member 2

BPI fold-containing family B member 2 (BPIFB2) also known as bactericidal/permeability-increasing protein-like 1 (BPI-like 1) is a protein that in humans is encoded by the BPIFB2 gene.[5][6]

BPIFB2
Identifiers
Aliases	BPIFB2, BPIL1, C20orf184, LPLUNC2, RYSR, dJ726C3.2, BPI fold containing family B member 2
External IDs	OMIM: 614108 MGI: 1913807 HomoloGene: 11884 GeneCards: BPIFB2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 33,007,704 bp[1] End 33,023,703 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 153,875,045 bp[2] End 153,895,270 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • lipid binding Cellular component • extracellular exosome • extracellular region • extracellular • endoplasmic reticulum lumen Biological process • antimicrobial humoral response • post-translational modification • cellular protein metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80341	66557
Ensembl	ENSG00000078898	ENSMUSG00000027481
UniProt	Q8N4F0	Q8C1E1
RefSeq (mRNA)	NM_025227	NM_025631
RefSeq (protein)	NP_079503	NP_079907
Location (UCSC)	Chr 20: 33.01 – 33.02 Mb	Chr 2: 153.88 – 153.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000078898 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027481 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mulero JJ, Boyle BJ, Bradley S, Bright JM, Nelken ST, Ho TT, Mize NK, Childs JD, Ballinger DG, Ford JE, Rupp F (Aug 2002). "Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)". Immunogenetics. 54 (5): 293–300. doi:10.1007/s00251-002-0467-3. PMID 12185532.
6. "Entrez Gene: BPIL1 bactericidal/permeability-increasing protein-like 1".

External links

• Human BPIFB2 genome location and BPIFB2 gene details page in the UCSC Genome Browser.

Further reading

• Bingle CD, Bingle L (2000). "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochim. Biophys. Acta. 1493 (3): 363–7. doi:10.1016/S0167-4781(00)00196-2. PMID 11018263.
• Bingle CD, Craven CJ (2003). "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx". Hum. Mol. Genet. 11 (8): 937–43. doi:10.1093/hmg/11.8.937. PMID 11971875.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Ramachandran P, Boontheung P, Xie Y, et al. (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002.