Bridging integrator 3

Bridging integrator 3 is a protein that in humans is encoded by the BIN3 gene.[5][6]

BIN3
Identifiers
Aliases	BIN3, bridging integrator 3
External IDs	OMIM: 606396 MGI: 1929883 HomoloGene: 5472 GeneCards: BIN3
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 22,620,418 bp[1] End 22,669,148 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D2 Start 70,100,105 bp[2] End 70,138,206 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytoskeletal adaptor activity • GO:0001948 protein binding • cytoskeletal protein binding • lipid binding Cellular component • cytoplasm • cytoskeleton • actin filament • actin cortical patch Biological process • regulation of lamellipodium assembly • unidimensional cell growth • protein localization • division septum assembly • cell cycle • myoblast migration involved in skeletal muscle regeneration • skeletal muscle fiber development • skeletal muscle tissue regeneration • actin filament organization • cell division • cytoskeleton-dependent cytokinesis • endocytosis • actin cortical patch localization • plasma membrane tubulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55909	57784
Ensembl	ENSG00000147439	ENSMUSG00000022089
UniProt	Q9NQY0	Q9JI08
RefSeq (mRNA)	NM_018688 NM_001363046	NM_021328 NM_001360404
RefSeq (protein)	NP_061158 NP_001349975	NP_067303 NP_001347333
Location (UCSC)	Chr 8: 22.62 – 22.67 Mb	Chr 14: 70.1 – 70.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene is a member of the BAR domain protein family. The encoded protein is composed solely of a BAR domain which is predicted to form coiled coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000147439 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022089 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ren G, Vajjhala P, Lee JS, Winsor B, Munn AL (Mar 2006). "The BAR domain proteins: molding membranes in fission, fusion, and phagy". Microbiol Mol Biol Rev. 70 (1): 37–120. doi:10.1128/MMBR.70.1.37-120.2006. PMC 1393252. PMID 16524918.
6. "Entrez Gene: BIN3 bridging integrator 3".

External links

• Human BIN3 genome location and BIN3 gene details page in the UCSC Genome Browser.

Further reading

• Habermann B (2004). "The BAR-domain family of proteins: a case of bending and binding?". EMBO Rep. 5 (3): 250–5. doi:10.1038/sj.embor.7400105. PMC 1299016. PMID 14993925.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Routhier EL, Burn TC, Abbaszade I, et al. (2001). "Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p". J. Biol. Chem. 276 (24): 21670–7. doi:10.1074/jbc.M101096200. PMID 11274158.