BDP1

Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.[5][6][7]

BDP1
Identifiers
AliasesBDP1, HSA238520, TAF3B1, TFC5, TFIIIB, TFIIIB150, TFIIIB90, TFNR, B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, DFNB112
External IDsOMIM: 607012 MGI: 1347077 HomoloGene: 34582 GeneCards: BDP1
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q13.2Start71,455,651 bp[1]
End71,567,820 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55814

544971

Ensembl

ENSG00000274803
ENSG00000273873
ENSG00000145734

ENSMUSG00000049658

UniProt

A6H8Y1
H7C5U4

Q571C7

RefSeq (mRNA)

NM_018429

NM_001081061

RefSeq (protein)

NP_060899

NP_001074530

Location (UCSC)Chr 5: 71.46 – 71.57 MbChr 13: 100.02 – 100.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.[7]

References

Further reading


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