BCL2L14

Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.[5][6]

BCL2L14
Identifiers
Aliases	BCL2L14, BCLG, BCL2 like 14
External IDs	OMIM: 606126 MGI: 1914063 HomoloGene: 49840 GeneCards: BCL2L14
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 12,049,844 bp[1] End 12,211,084 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 134,396,318 bp[2] End 134,438,736 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein kinase binding Cellular component • intracellular organelle • membrane • endomembrane system • cytosol • cytoplasm Biological process • positive regulation of extrinsic apoptotic signaling pathway • apoptotic process • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79370	66813
Ensembl	ENSG00000281449 ENSG00000121380	ENSMUSG00000030200
UniProt	Q9BZR8	Q9CPT0
RefSeq (mRNA)	NM_030766 NM_138722 NM_138723 NM_138724 NM_001370268 NM_001370269	NM_025778 NM_001355686
RefSeq (protein)	NP_110393 NP_620048 NP_620049 NP_001357197 NP_001357198	NP_080054 NP_001342615
Location (UCSC)	Chr 12: 12.05 – 12.21 Mb	Chr 6: 134.4 – 134.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Four alternatively spliced transcript variants, which encode three distinct isoforms, have been reported for this gene.[6]

References

1. ENSG00000121380 GRCh38: Ensembl release 89: ENSG00000281449, ENSG00000121380 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030200 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Guo B, Godzik A, Reed JC (May 2001). "Bcl-G, a novel pro-apoptotic member of the Bcl-2 family". J Biol Chem. 276 (4): 2780–5. doi:10.1074/jbc.M005889200. PMID 11054413.
6. "Entrez Gene: BCL2L14 BCL2-like 14 (apoptosis facilitator)".

External links

• Human BCL2L14 genome location and BCL2L14 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Montpetit A, Boily G, Sinnett D (2002). "A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus". European Journal of Human Genetics. 10 (1): 62–71. doi:10.1038/sj.ejhg.5200766. PMID 11896457.
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
• Ozalp SS, Yalcin OT, Tanir HM, et al. (2003). "Bcl-2 expression in preinvasive and invasive cervical lesions". Eur. J. Gynaecol. Oncol. 23 (5): 419–22. PMID 12440815.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Montpetit A, Larose J, Boily G, et al. (2004). "Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia". Leukemia. 18 (9): 1499–504. doi:10.1038/sj.leu.2403441. PMID 15284860.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Soung YH, Lee JW, Park WS, et al. (2006). "BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder". Pathology. 38 (1): 33–4. doi:10.1080/00313020500455811. PMID 16484005.
• Lin ML, Park JH, Nishidate T, et al. (2007). "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family". Breast Cancer Res. 9 (1): R17. doi:10.1186/bcr1650. PMC 1851384. PMID 17280616.
• Yoo NJ, Soung YH, Lee SH, et al. (2007). "Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas". Tumori. 93 (2): 195–7. PMID 17557568.