BCAP31

B-cell receptor-associated protein 31 is a protein that in humans is encoded by the BCAP31 gene.[5]

BCAP31
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JZL, 4JZP
Identifiers
Aliases	BCAP31, 6C6-AG, BAP31, CDM, DDCH, DXS1357E, B-cell receptor-associated protein 31, B-cell receptor associated protein 31, B cell receptor associated protein 31
External IDs	OMIM: 300398 MGI: 1350933 HomoloGene: 38095 GeneCards: BCAP31
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 153,700,492 bp[1] End 153,724,565 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 73,686,178 bp[2] End 73,716,175 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0032403 macromolecular complex binding • GO:0001948 protein binding • MHC class I protein binding Cellular component • integral component of membrane • cytosol • endoplasmic reticulum membrane • membrane • Sec61 translocon complex • Golgi membrane • lipid droplet • perinuclear endoplasmic reticulum • integral component of plasma membrane • Golgi cisterna membrane • endoplasmic reticulum • integral component of lumenal side of endoplasmic reticulum membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • clathrin-coated vesicle • mitochondrion Biological process • antigen processing and presentation of peptide antigen via MHC class I • positive regulation of cytosolic calcium ion concentration • positive regulation of retrograde protein transport, ER to cytosol • positive regulation of ER-associated ubiquitin-dependent protein catabolic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • spermatogenesis • protein transport • negative regulation of endoplasmic reticulum calcium ion concentration • positive regulation of mitochondrial calcium ion concentration • intracellular protein transport • calcium-mediated signaling using intracellular calcium source • positive regulation of intrinsic apoptotic signaling pathway • vesicle-mediated transport • apoptotic process • ER to Golgi vesicle-mediated transport • protein localization to endoplasmic reticulum exit site • execution phase of apoptosis • transport • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10134	27061
Ensembl	ENSG00000185825	ENSMUSG00000002015
UniProt	P51572	Q61335
RefSeq (mRNA)	NM_005745 NM_001139441 NM_001139457 NM_001256447	NM_012060 NM_001313698
RefSeq (protein)	NP_001132913 NP_001132929 NP_001243376 NP_005736	NP_001300627 NP_036190
Location (UCSC)	Chr X: 153.7 – 153.72 Mb	Chr X: 73.69 – 73.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

BCAP31 has been shown to interact with:

• APP,[6]
• BCL2L1,[7]
• BCL2,[7]
• CASP8,[7] and
• VAMP3.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000185825 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002015 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: BCAP31 B-cell receptor-associated protein 31".
6. Wang B, Nguyen M, Breckenridge DG, Stojanovic M, Clemons PA, Kuppig S, Shore GC (Apr 2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria". J. Biol. Chem. 278 (16): 14461–8. doi:10.1074/jbc.M209684200. PMID 12529377.
7. Ng FW, Nguyen M, Kwan T, Branton PE, Nicholson DW, Cromlish JA, Shore GC (Oct 1997). "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum". J. Cell Biol. 139 (2): 327–38. doi:10.1083/jcb.139.2.327. PMC 2139787. PMID 9334338.
8. Annaert WG, Becker B, Kistner U, Reth M, Jahn R (Dec 1997). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.

Further reading

• Mosser J, Sarde CO, Vicaire S, et al. (1995). "A new human gene (DXS1357E) with ubiquitous expression, located in Xq28 adjacent to the adrenoleukodystrophy gene". Genomics. 22 (2): 469–71. doi:10.1006/geno.1994.1413. PMID 7806238.
• Sora I, Richman J, Santoro G, et al. (1994). "The cloning and expression of a human creatine transporter". Biochem. Biophys. Res. Commun. 204 (1): 419–27. doi:10.1006/bbrc.1994.2475. PMID 7945388.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Adachi T, Schamel WW, Kim KM, et al. (1996). "The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence". EMBO J. 15 (7): 1534–41. doi:10.1002/j.1460-2075.1996.tb00497.x. PMC 450061. PMID 8612576.
• Li E, Bestagno M, Burrone O (1996). "Molecular cloning and characterization of a transmembrane surface antigen in human cells". Eur. J. Biochem. 238 (3): 631–8. doi:10.1111/j.1432-1033.1996.0631w.x. PMID 8706661.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
• Ng FW, Nguyen M, Kwan T, et al. (1997). "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum". J. Cell Biol. 139 (2): 327–38. doi:10.1083/jcb.139.2.327. PMC 2139787. PMID 9334338.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Annaert WG, Becker B, Kistner U, et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.
• Nguyen M, Breckenridge DG, Ducret A, Shore GC (2000). "Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria". Mol. Cell. Biol. 20 (18): 6731–40. doi:10.1128/MCB.20.18.6731-6740.2000. PMC 86192. PMID 10958671.
• Bell AW, Ward MA, Blackstock WP, et al. (2001). "Proteomics characterization of abundant Golgi membrane proteins". J. Biol. Chem. 276 (7): 5152–65. doi:10.1074/jbc.M006143200. PMID 11042173.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Spiliotis ET, Manley H, Osorio M, et al. (2001). "Selective export of MHC class I molecules from the ER after their dissociation from TAP". Immunity. 13 (6): 841–51. doi:10.1016/S1074-7613(00)00081-9. PMID 11163199.
• Manley HA, Lennon VA (2001). "Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells". J. Histochem. Cytochem. 49 (10): 1235–43. doi:10.1177/002215540104901005. PMID 11561007.
• Zuppini A, Groenendyk J, Cormack LA, et al. (2002). "Calnexin deficiency and endoplasmic reticulum stress-induced apoptosis". Biochemistry. 41 (8): 2850–8. doi:10.1021/bi015967+. PMID 11851433.
• Breckenridge DG, Nguyen M, Kuppig S, et al. (2002). "The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4331–6. doi:10.1073/pnas.072088099. PMC 123648. PMID 11917123.
• Corzo D, Gibson W, Johnson K, et al. (2002). "Contiguous deletion of the X-linked adrenoleukodystrophy gene (ABCD1) and DXS1357E: a novel neonatal phenotype similar to peroxisomal biogenesis disorders". Am. J. Hum. Genet. 70 (6): 1520–31. doi:10.1086/340849. PMC 419992. PMID 11992258.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang B, Nguyen M, Breckenridge DG, et al. (2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria". J. Biol. Chem. 278 (16): 14461–8. doi:10.1074/jbc.M209684200. PMID 12529377.
• Mund T, Gewies A, Schoenfeld N, et al. (2003). "Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum". FASEB J. 17 (6): 696–8. doi:10.1096/fj.02-0657fje. PMID 12594175.

External links

• BCAP31 human gene location in the UCSC Genome Browser.
• BCAP31 human gene details in the UCSC Genome Browser.