Azoximer bromide

Azoximer bromide, sold by the trade name Polyoxidonium, is a macromolecular compound with high-molecular weight and high immunomodulating activity. It is used in Russia and CIS in treatment and prophylaxis of diseases connected with damage of immune system. It is a N-oxidized polyethylene–piperazine derivative.

Azoximer bromide
Clinical data
Other namesPolyoxidonium, Synpol
ATC code
Pharmacokinetic data
Bioavailabilityup to 89%
Elimination half-life25.4 hours (intravenous routes)
Identifiers
CAS Number
ChemSpider
  • none
UNII
Chemical and physical data
Formula[[C8H15BrN2O2]x[C6H12N2O]y]n
Molar mass60000–100000 g/mol

Azoximer bromide is registered in US Patent-5503830 from 1996,[1][2][3] in the Russian Federation from 1996, under registration number 96/302/9, FS 42-3906-00.[4]

History

Polyoxidonium was created at the State Scientific Center of the Institute of Immunology of the Ministry of Health of the Russian Federation[5]. It is produced by NPO Petrovax Pharm LLC[6].

Medical uses

In adults with secondary immunodeficient states as:

  • relapsing chronic bacterial infections
  • relapsing chronic viral infections
  • acute bacterial infections
  • acute viral infections
  • allergic diseases (pollinosis, bronchial asthma, atopic dermatitis)
  • severe septic states
  • postoperative complications - purulent infections
  • when primary treatment develops cellular immunity decrease (cytostatic treatment, X-rays)
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References
  1. https://www.google.com/patents/about?id=s9cfAAAAEBAJ&dq=US+5503830
  2. http://www.wikipatents.com/US-Patent-5503830/compounds-having-immunostimulating-activity-and-methods-of-use-thereof%5B%5D
  3. http://www.freepatentsonline.com/EP0789586.html
  4. State Scientific Centre of Russian federation, Immunological Institute of Russian Federation Health Resort, CLINICAL ASPECTS OF USE OF IMMUNOMODULATOR POLYOXIDONIUM, Methodical handbook for doctors issued by State Scientific Centre of Russian Federation – Immunological Institute of Russian Federation Health Resort Moscow – 2003
  5. Некрасов А. В., Пучкова Н. Г., Иванова А. С. и др. Производное поли-1,4-этиленпиперазина, обладающее иммуномодулирующей, противовирусной и антибактериальной активностью. Пат. РФ № 2073031, 1997.
  6. http://petrovax.com/medication/catalog/polyoxydonium/


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