Autophagy-related protein 13

Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene.[5]

ATG13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5C50
Identifiers
Aliases	ATG13, KIAA0652, PARATARG8, autophagy related 13
External IDs	OMIM: 615088 MGI: 1196429 HomoloGene: 32229 GeneCards: ATG13
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 46,617,527 bp[1] End 46,674,818 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 91,674,618 bp[2] End 91,710,576 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • protein kinase binding Cellular component • cytoplasm • cytosol • ATG1/ULK1 kinase complex • mitochondrion • pre-autophagosomal structure • endoplasmic reticulum membrane Biological process • autophagy • macroautophagy • autophagosome assembly • positive regulation of protein targeting to mitochondrion • mitophagy • response to mitochondrial depolarisation • regulation of macroautophagy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9776	51897
Ensembl	ENSG00000175224	ENSMUSG00000027244
UniProt	O75143	Q91YI1
RefSeq (mRNA)	NM_001142673 NM_001205119 NM_001205120 NM_001205121 NM_001205122 NM_001346311 NM_001346312 NM_001346313 NM_001346314 NM_001346315 NM_001346316 NM_001346317 NM_001346318 NM_001346319 NM_001346320 NM_001346321 NM_001346322 NM_001346323 NM_001346324 NM_001346325 NM_001346326 NM_001346327 NM_001346328 NM_001346329 NM_001346330 NM_001346331 NM_001346332 NM_001346333 NM_001346334 NM_001346335 NM_001346336 NM_001346337 NM_001346338 NM_001346340 NM_001346342 NM_001346344 NM_001346346 NM_001346348 NM_001346349 NM_001346350 NM_001346351 NM_001346352 NM_001346353 NM_001346354 NM_001346355 NM_001346356 NM_001346357 NM_001346358 NM_001346359 NM_001346360 NM_014741	NM_145528 NM_001355416 NM_001355417 NM_001355418 NM_001355419 NM_001355420 NM_001355421
RefSeq (protein)	NP_001136145 NP_001192048 NP_001192049 NP_001192050 NP_001192051 NP_001333240 NP_001333241 NP_001333242 NP_001333243 NP_001333244 NP_001333245 NP_001333246 NP_001333247 NP_001333248 NP_001333249 NP_001333250 NP_001333251 NP_001333252 NP_001333253 NP_001333254 NP_001333255 NP_001333256 NP_001333257 NP_001333258 NP_001333259 NP_001333260 NP_001333261 NP_001333262 NP_001333263 NP_001333264 NP_001333265 NP_001333266 NP_001333267 NP_001333269 NP_001333271 NP_001333273 NP_001333275 NP_001333277 NP_001333278 NP_001333279 NP_001333280 NP_001333281 NP_001333282 NP_001333283 NP_001333284 NP_001333285 NP_001333286 NP_001333287 NP_001333288 NP_001333289 NP_055556	NP_663503 NP_001342345 NP_001342346 NP_001342347 NP_001342348 NP_001342349 NP_001342350
Location (UCSC)	Chr 11: 46.62 – 46.67 Mb	Chr 2: 91.67 – 91.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.[6][7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000175224 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027244 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KIAA0652".
6. Mercer CA, Kaliappan A, Dennis PB (July 2009). "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy". Autophagy. 5 (5): 649–62. doi:10.4161/auto.5.5.8249. PMID 19287211.
7. Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy". Mol. Biol. Cell. 20 (7): 1981–91. doi:10.1091/mbc.E08-12-1248. PMC 2663915. PMID 19211835.
8. Chan EY, Longatti A, McKnight NC, Tooze SA (January 2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.

External links

• Human ATG13 genome location and ATG13 gene details page in the UCSC Genome Browser.

Further reading

• Hosokawa N, Sasaki T, Iemura S, et al. (2009). "Atg101, a novel mammalian autophagy protein interacting with Atg13". Autophagy. 5 (7): 973–9. doi:10.4161/auto.5.7.9296. PMID 19597335.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Chan EY (2009). "mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex". Science Signaling. 2 (84): pe51. doi:10.1126/scisignal.284pe51. PMID 19690328.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Jung CH, Jun CB, Ro SH, et al. (2009). "ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery". Mol. Biol. Cell. 20 (7): 1992–2003. doi:10.1091/mbc.E08-12-1249. PMC 2663920. PMID 19225151.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Chan EY, Longatti A, McKnight NC, Tooze SA (2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.
• Ganley IG, Lam du H, Wang J, et al. (2009). "ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy". J. Biol. Chem. 284 (18): 12297–305. doi:10.1074/jbc.M900573200. PMC 2673298. PMID 19258318.
• Sinzelle L, Kapitonov VV, Grzela DP, et al. (2008). "Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes". Proc. Natl. Acad. Sci. U.S.A. 105 (12): 4715–20. doi:10.1073/pnas.0707746105. PMC 2290759. PMID 18339812.