Autoimmune/inflammatory syndrome induced by adjuvants

Autoimmune/inflammatory syndrome induced by adjuvants, also known as Shoenfeld's syndrome or ASIA, is a theoretical autoimmune disorder proposed by Israeli immunologist Yehuda Shoenfeld in 2011.[1] According to Shoenfeld, the syndrome includes four conditions: "post-vaccination symptoms," macrophagic myofasciitis, Gulf war syndrome, sick building syndrome, and siliconosis.[2][3] Shoenfeld alleges that the syndrome is caused by adjuvants such as silicone, tetramethylpentadecane, pristane, and aluminum.[4] However, causality is difficult to prove because ASIA only occurs in a small fraction of patients exposed to these adjuvants.[5] Additionally, proponents of this theory allege that the disorder can manifest anywhere from 2 days to 23 years after exposure.[3] Shoenfeld has also named Sjögren's syndrome as potentially being another facet of ASIA.[6] In 2013, the authors of a textbook on autoimmune diseases concluded that "there exists persuasive evidence for ASIA," but noted that several academic and governmental agencies had dismissed the possibility of a link between silicone and autoimmune disease.[7]

However, apart from the theoretical concept of ASIA, there is a lack of reproducible evidence for any causal relationship between adjuvant and autoimmune condition.[8] A study of 18,000 people showed that there is no merit to the theory of autoimmune/inflammatory syndrome induced by adjuvants.[9]

  • "Autoimmune syndromes induced by adjuvants – Shoenfeld vaccine myth". Skeptical Raptor. 2019-07-09. Retrieved 2020-01-29.
gollark: I have a working... I think ~4 year old one?
gollark: No.
gollark: Why would you just randomly replace SSDs every year?
gollark: SSDs still cost ~4x more per GB and the reliability is not that different in a stationary system.
gollark: Depends on use pattern - do you want to read only, or read and write lots, or what? In general probably not.

References
  1. Shoenfeld, Yehuda (2013). "Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld". BMC Medicine. 11 (1): 118. doi:10.1186/1741-7015-11-118. PMC 3662178. PMID 23635355.
  2. Vera-Lastra, O; Medina, G; Cruz-Dominguez Mdel, P; Jara, LJ; Shoenfeld, Y (April 2013). "Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome): clinical and immunological spectrum". Expert Review of Clinical Immunology. 9 (4): 361–73. doi:10.1586/eci.13.2. PMID 23557271.
  3. Elwood, J. Mark; Linneberg, Allan; Gold, Michael; Gillis, David; Ameratunga, Rohan (1 November 2017). "Evidence Refuting the Existence of Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA)". The Journal of Allergy and Clinical Immunology: In Practice. 5 (6): 1551–1555.e1. doi:10.1016/j.jaip.2017.06.033. ISSN 2213-2198. PMID 28888842. Retrieved 5 May 2019.
  4. Perricone, Carlo; Colafrancesco, Serena; Mazor, Roei D.; Soriano, Alessandra; Agmon-Levin, Nancy; Shoenfeld, Yehuda (December 2013). "Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects". Journal of Autoimmunity. 47: 1–16. doi:10.1016/j.jaut.2013.10.004. PMID 24238833.
  5. West, Sterling (2014). Rheumatology Secrets. Elsevier. p. 597. ISBN 9780323172875.
  6. Colafrancesco, S.; Perricone, C.; Priori, R.; Valesini, G.; Shoenfeld, Y. (June 2014). "Sjögren's syndrome: Another facet of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA)". Journal of Autoimmunity. 51: 10–16. doi:10.1016/j.jaut.2014.03.003.
  7. The Autoimmune Diseases: 5th Edition. The Academic Press. 2013. pp. 1127–1128. ISBN 9780123849304.
  8. Hawkes D.; et al. (May 2015). "Revisiting adverse reactions to vaccines: A critical appraisal of Autoimmune Syndrome Induced by Adjuvants (ASIA)". J. Autoimmun. 59: 77–84. doi:10.1016/j.jaut.2015.02.005. PMID 25794485.
  9. Philadelphia, The Children's Hospital of (17 September 2018). "Vaccines and Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA)". www.chop.edu. Retrieved 5 May 2019.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.