Aurein
This family of antibacterial peptides are secreted from the granular dorsal glands of Litoria aurea (Green and golden bell frog), Litoria raniformis (Southern bell frog), Litoria citropa (Australian blue mountains tree frog) and frogs from genus Uperoleia. Amongst the more active of these are aurein 1.2, aurein 2.2 and aurein 3.1; caerin 1.1, maculatin 1.1, uperin 3.6;[1] citropin 1.1, citropin 1.2, citropin 1.3 and a minor peptide are wide-spectrum antibacterial peptides.[2][3]
| Antimicrobial20 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Antimicrobial20 | ||||||||
| Pfam | PF08256 | ||||||||
| InterPro | IPR013157 | ||||||||
| TCDB | 1.C.76 | ||||||||
| OPM superfamily | 211 | ||||||||
| OPM protein | 1vm5 | ||||||||
| |||||||||
References
- Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ (September 2000). "The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2 >". Eur. J. Biochem. 267 (17): 5330–41. doi:10.1046/j.1432-1327.2000.01536.x. PMID 10951191.
- Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ (October 1999). "Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1". Eur. J. Biochem. 265 (2): 627–37. doi:10.1046/j.1432-1327.1999.00750.x. PMID 10504394.
- Shahmiri, Mahdi; Enciso, Marta; Mechler, Adam (17 November 2015). "Controls and constrains of the membrane disrupting action of Aurein 1.2". Scientific Reports. 5 (1): 16378. Bibcode:2015NatSR...516378S. doi:10.1038/srep16378. PMC 4648102. PMID 26574052.
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