Archain 1

ARCN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
Identifiers
Aliases	ARCN1, COPD, archain 1, SRMMD
External IDs	OMIM: 600820 MGI: 2387591 HomoloGene: 1250 GeneCards: ARCN1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	118,603,033 bp[1]
Gene ontology
Molecular function	• RNA binding;
Cellular component	• cytosol; • membrane; • Golgi membrane; • COPI-coated vesicle membrane; • transport vesicle; • endoplasmic reticulum; • COPI vesicle coat; • cytoplasmic vesicle; • COPI-coated vesicle; • endoplasmic reticulum membrane; • cytoplasm; • Golgi apparatus;
Biological process	• retrograde vesicle-mediated transport, Golgi to ER; • cerebellar Purkinje cell layer maturation; • adult locomotory behavior; • ER to Golgi vesicle-mediated transport; • Golgi vesicle transport; • protein transport; • pigmentation; • intracellular protein transport; • vesicle-mediated transport; • transport; • Golgi localization;
	Sources:Amigo / QuickGO
Orthologs
	372
	213827
	ENSG00000095139
	n/a
	P48444
	Q5XJY5
	NM_001142281; NM_001655
	NM_145985
	NP_001135753; NP_001646
	NP_666097
	Wikidata
View/Edit Human	View/Edit Mouse

Archain 1 is a protein that in humans is encoded by the ARCN1 gene. [4]

Function

This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or vesicle trafficking.

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References

GRCh38: Ensembl release 89: ENSG00000095139 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Archain 1". Retrieved 2016-06-22.

Deng K, Gao F, Zheng P, Gong W, Sun Z (2012). "Crystallization and preliminary X-ray analysis of the C-terminal domain of δ-COP, a medium-sized subunit of the COPI complex involved in membrane trafficking". Acta Crystallographica Section F. 68 (Pt 7): 829–31. doi:10.1107/S1744309112022798. PMC 3388933. PMID 22750876.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095139 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: Archain 1". Retrieved 2016-06-22.

Archain 1

Function

References

Further reading