Aquaretic

An aquaretic is a novel class of drug that is used to promote aquaresis, the excretion of water without electrolyte loss.[1] Strictly speaking, aquaretics are not diuretics, but are sometimes classified as such.

Aquaresis is preferable to diuresis in the treatment of hyponatremia.

Pharmacokinetics

Aquaretics increase urine output without increasing sodium and chloride excretion, thus causing an increase in urine whilst retaining electrolytes.[2]

Examples

A number of herbal medicines are classified as aquaretics, for example common horsetail or common nettle leaves.[3]

Synthetic aquaretics are vasopressin receptor antagonists, such conivaptan, tolvaptan, demeclocycline and mozavaptan (OPC-31260), as well as lithium. Conivaptan hydrochloride and tolvaptan have been approved by the FDA for treating syndrome of inappropriate antidiuretic hormone (SIADH). [4][5] Mozavaptan is approved in Japan.

gollark: Oh, correction, every *five* seconds.
gollark: ```03-01 21:54:43.706 492 492 F libc : Fatal signal 11 (SIGSEGV), code 1 (SEGV_MAPERR), fault addr 0x0 in tid 492 (recovery), pid 492 (recovery)03-01 21:54:43.707 494 494 F libc : failed to exec crash_dump helper: No such file or directory03-01 21:54:43.708 492 492 F libc : crash_dump helper failed to exec03-01 21:54:48.709 496 496 W libc : Unable to set property "ro.twrp.boot" to "1": error code: 0xb03-01 21:54:48.710 496 496 W libc : Unable to set property "ro.twrp.version" to "3.4.0-TEST_MRMAZAK_10": error code: 0xb03-01 21:54:48.711 496 496 F libc : Fatal signal 11 (SIGSEGV), code 1 (SEGV_MAPERR), fault addr 0x0 in tid 496 (recovery), pid 496 (recovery)03-01 21:54:48.714 498 498 F libc : failed to exec crash_dump helper: No such file or directory03-01 21:54:48.715 496 496 F libc : crash_dump helper failed to exec03-01 21:54:53.721 499 499 W libc : Unable to set property "ro.twrp.boot" to "1": error code: 0xb03-01 21:54:53.721 499 499 W libc : Unable to set property "ro.twrp.version" to "3.4.0-TEST_MRMAZAK_10": error code: 0xb03-01 21:54:53.722 499 499 F libc : Fatal signal 11 (SIGSEGV), code 1 (SEGV_MAPERR), fault addr 0x0 in tid 499 (recovery), pid 499 (recovery)03-01 21:54:53.724 501 501 F libc : failed to exec crash_dump helper: No such file or directory03-01 21:54:53.725 499 499 F libc : crash_dump helper failed to exec```It seems to log this every few times a second, how amazing!
gollark: If it comes to it I *think* I can reflash it from the "MTK scatter tool" but this would require me to find a windows computer somewhere and such.
gollark: Or fastboot.
gollark: I can get *recovery mode*, but only a somewhat broken recovery mode which lets me run shell commands somehow but which does not seem to want to actually boot into system mode, *somehow*.

References
  1. Nicholas H. Fiebach; Lee Randol Barker (2007). Principles of Ambulatory Medicine. Lippincott Williams & Wilkins. p. 1390. ISBN 0-7817-6227-8.
  2. George M. Brenner; Craig W. Stevens (2013). Phamacology. Elsevier Inc. pp. 120–129. ISBN 978-1455702824.
  3. Lucinda G. Miller; Wallace J. Murray (1998). Herbal Medicinals: A Clinician's Guide. Haworth Press. pp. 147. ISBN 0-7890-0466-6.
  4. "Vaprisol" (PDF). fda.gov. 31 December 2005. Retrieved 6 January 2019.
  5. "Samsca" (PDF). fda.gov. 31 May 2009. Retrieved 6 January 2019.


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