Anti-apoptotic Ras signalling cascade

The Anti-apoptotic Ras signaling cascade is an intracellular signal transduction cascade that involves the Ras protein and inhibits apoptosis. It is the target of the cancer drug gefitinib.

It may refer to the PI3K/AKT pathway.[1][2][3]

It may refer to the MAPK/ERK pathway which involves ras and can affect apoptosis.[4][5]

The anti-apoptotic STAT pathway does not involve Ras.

See also
  • Ras subfamily

References
  1. Sordella, R; Bell, DW; Haber, DA; Settleman, J (August 2004). "Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways". Science. 305 (5687): 1163–7. Bibcode:2004Sci...305.1163S. doi:10.1126/science.1101637. PMID 15284455.
  2. http://genesdev.cshlp.org/content/11/6/701.abstract "The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal" 1997
  3. Zhuravliova, E.; Barbakadze, T.; Narmania, N.; Sepashvili, M.; Mikeladze, D. G. (2008). "Hypoinsulinemia Alleviates the Grf1/Ras/Akt Anti-Apoptotic Pathway and Induces Alterations of Mitochondrial Ras Trafficking in Neuronal Cells". Neurochemical Research. 34 (6): 1076–1082. doi:10.1007/s11064-008-9877-4. PMID 19002579.
  4. http://cancerres.aacrjournals.org/cgi/content/abstract/67/21/10343 "Suppression of PTEN Expression Is Essential for Antiapoptosis and Cellular Transformation by Oncogenic Ras" 2007
  5. http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/972-b "Pathways potentiated by oncogenic Ras to modulate apoptosis induced by anticancer agent FR901228 " 2005
  • Diagram of ras onwards.


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