Anthera Pharmaceuticals

Anthera Pharmaceuticals, Inc. is an American biopharmaceutical company focused on developing and commercializing products to treat serious conditions associated with cystic fibrosis, inflammation and autoimmune diseases. Liprotamase (Sollpura), Anthera’s leading drug candidate which is being developed for exocrine pancreatic insufficiency (EPI) is currently in Phase 3 clinical trials, and A-623 (Blisibimod) for the treatment of IgA nephropathy[1][2] is currently in Phase 2 clinical trial.

Anthera Pharmaceuticals, Inc.
Public
Traded asNASDAQ: ANTH
IndustryPharmaceuticals
Founded2004
HeadquartersHayward, California, U.S.
Key people
Craig Thompson
(President and CEO)
WebsiteAnthera.com

Products

Blisibimod
  • Blisibimod is a selective peptibody antagonist of B-cell activating factor (BAFF). BAFF is critical to the development, maintenance and survival of B-cells, but is known to be up-regulated in autoimmune diseases.[3][4][5] It is primarily expressed by macrophages, monocytes and dendritic cells.[6] Blisibimod binds to BAFF and inhibits the interaction of BAFF with its receptors.[7] Blisibimod is currently being evaluated in IgA nephropathy .

Sollpura

July 2014, Anthera acquired Sollpura (Liprotamase) from Eli Lilly and Company.[8] Sollpura is an investigational pancreatic enzyme replacement therapy (PERT) that uses three biotechnology-derived digestive enzymes intended to treat patients with endocrine pancreatic insufficiency as a result of cystic fibrosis and other diseases.[9]

gollark: ... seriously?!
gollark: In any case, maybe I'm just used to hilariously powerful mods, but a turtle which digs slowly and might randomly break is just... not very good compared to a quarry.
gollark: Er, you need three diamonds.
gollark: Where it shines is in performing random useful tasks which there isn't dedicated hardware available for, linking together disparate systems (much more practically than redstone), working as a "microcontroller" to control something based on a bunch of input data, and entertainment-/decorative-type things (displaying stuff on monitors and whatnot, and music with Computronics).
gollark: For example, quarrying. CC has turtles. They can dig things. They can move. You can make a quarry out of this, and people have. But in practice, they're not hugely fast or efficient, and it's hard to make it work well in the face of stuff like server restarts, while a dedicated quarrying device from a mod will handle this fine and probably go faster if you can power it somehow.

References
  1. "Overview". Anthera Pharmaceuticals, Inc. Archived from the original on August 21, 2014. Retrieved August 11, 2014.
  2. "Management Team". Anthera Pharmaceuticals, Inc. Anthera Pharmaceuticals, Inc. Archived from the original on August 12, 2014. Retrieved August 11, 2014.
  3. Groom, J; Kalled, SL; Cutler, AH; Olson, C; Woodcock, SA; Schneider, P; Tschopp, J; Cachero, TG; Batten, M; Wheway, J; Mauri, D; Cavill, D; Gordon, TP; Mackay, CR; Mackay, F (Jan 2002). "Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome". J Clin Invest. 109 (1): 59–68. doi:10.1172/JCI14121. PMC 150825. PMID 11781351.
  4. Petri, Michelle; Stohl, William; Chatham, Winn; McCune, Joseph; Chevrier, Marc; Ryel, Jeff; Recta, Virginia; Zhong, John; Freimuth, William. "ARTHRITIS & RHEUMATISM Vol. 58, No. 8, August 2008, pp 2453–2459 DOI 10.1002/art.23678 © 2008, American College of Rheumatology Association of Plasma B Lymphocyte Stimulator Levels and Disease Activity in Systemic Lupus Erythematosus" (PDF). Deepblue. American College of Rheumatology. Retrieved August 11, 2014.
  5. Zhang, J; Roschke, K; Baker, KP; Wang, Z; Alarcon, GS; Fessler, BJ; Bastian, H; Kimberly, RP; Zhou, T (2001). "Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus". Journal of Immunology. J Immunol. 166 (1): 6–10. doi:10.4049/jimmunol.166.1.6. PMID 11123269.
  6. "Product Candidates". Anthera Pharmaceuticals, Inc. Anthera Pharmaceuticals, Inc. Archived from the original on August 16, 2014. Retrieved August 11, 2014.
  7. Hsu, H; Khare, SD; Lee, F; Miner, K; Hu, YL; Stolina, M; Hawkins, N; Chen, Q; Ho, SY; Min, H; Xiong, F; Boone, T; Zack, DJ. "A novel modality of BAFF-specific inhibitor AMG623 peptibody reduces B-cell number and improves outcomes in murine models of autoimmune disease". Clin Exp Rheumatol. Clinical and Experimentla Rheumatology. 30 (2): 197–201. PMID 22325420.
  8. "Anthera Pharmaceuticals Announces Acquisition of Sollpura® (liprotamase) for Exocrine Pancreatic Insufficiency From Eli Lilly and Company". Anthera Pharmaceuticals, Inc. Anthera Pharmaceuticals. Archived from the original on August 12, 2014. Retrieved August 11, 2014.
  9. "Anthera Pharmaceuticals Announces Acquisition of Sollpura® (liprotamase) for Exocrine Pancreatic Insufficiency From Eli Lilly and Company". Anthera Pharmaceuticals, Inc. Anthera Pharmaceuticals. Archived from the original on August 12, 2014. Retrieved August 11, 2014. Sollpura narrowly missed its target for Phase 3 of its clinical trials. It believes that specific conditions in the testing phase, specifically that patients were not able to increase dosages throughout the trial, negatively affected testing and led to the narrow shortcoming for Phase 3. It will conduct a new trial compensating for the perceived shortcoming at some point in the future.
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