Angiomotin-like protein 1

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.[5][6]

AMOTL1
Identifiers
Aliases	AMOTL1, JEAP, angiomotin like 1
External IDs	OMIM: 614657 MGI: 1922973 HomoloGene: 43977 GeneCards: AMOTL1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q21 Start 94,706,431 bp[1] End 94,876,748 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A2 Start 14,541,966 bp[2] End 14,645,056 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding Cellular component • COP9 signalosome • cytosol • apical plasma membrane • cytoplasmic vesicle • lamellipodium • bicellular tight junction • cell junction Biological process • establishment of cell polarity involved in ameboidal cell migration • Wnt signaling pathway • Hippo signaling pathway • positive regulation of blood vessel endothelial cell migration • actin cytoskeleton organization • regulation of cell migration • angiogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	154810	75723
Ensembl	ENSG00000166025	ENSMUSG00000013076
UniProt	Q8IY63	Q9D4H4
RefSeq (mRNA)	NM_001301007 NM_130847	NM_001081395
RefSeq (protein)	NP_001287936 NP_570899 NP_570899.1	NP_001074864
Location (UCSC)	Chr 11: 94.71 – 94.88 Mb	Chr 9: 14.54 – 14.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000166025 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000013076 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y (Feb 2002). "JEAP, a novel component of tight junctions in exocrine cells". J Biol Chem. 277 (7): 5583–7. doi:10.1074/jbc.M110154200. PMID 11733531.
6. "Entrez Gene: AMOTL1 angiomotin like 1".

External links

• Human AMOTL1 genome location and AMOTL1 gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Patrie KM (2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1". Biochim. Biophys. Acta. 1745 (1): 131–44. doi:10.1016/j.bbamcr.2005.05.011. PMID 16019084.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.