Angiomatoid fibrous histiocytoma

Angiomatoid fibrous histiocytoma, abbreviated AFH, is a rarely metastasizing tumour that affects children and young adults.

Angiomatoid fibrous histiocytoma
Micrograph showing a angiomatoid fibrous histiocytoma. H&E stain.

Pathology

It is characterized cystic blood-filled spaces and composed of histiocyte-like cells. A lymphocytic cuff is common. It often simulates a vascular lesion, and was initially described as doing this.[1]

AFH typically has a chromosomal translocation involving the ATF1 gene -- t(12;16) FUS/ATF1 or t(12;22) EWS/ATF1.

Diagnosis

Treatment
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See also

References
  1. Enzinger, FM. (Dec 1979). "Angiomatoid malignant fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm". Cancer. 44 (6): 2147–57. doi:10.1002/1097-0142(197912)44:6<2147::aid-cncr2820440627>3.0.co;2-8. PMID 228836.
Classification
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