Aminometradine

Aminometradine
Clinical data
ATC code	none;
Identifiers
	IUPAC name 6-Amino-3-ethyl-1-prop-2-enylpyrimidine-2,4-dione;
CAS Number	642-44-4;
PubChem CID	12551;
ChemSpider	12033 ;
UNII	PPM8SX5Q3V;
CompTox Dashboard (EPA)	DTXSID00214403 ;
ECHA InfoCard	100.010.350
Chemical and physical data
Formula	C9H13N3O2
Molar mass	195.222 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(/C(=C\C(=O)N1CC)N)C\C=C;
	InChI InChI=1S/C9H13N3O2/c1-3-5-12-7(10)6-8(13)11(4-2)9(12)14/h3,6H,1,4-5,10H2,2H3 ; Key:NGXUUAFYUCOICP-UHFFFAOYSA-N ;
	(verify)

Aminometradine is a weak diuretic which was used to control oedema in those who suffered mild congestive heart failure.

Alkyl uracil derivatives have been known for some time to act as diuretic agents in experimental animals. The toxicity of these agents precluded their use in the clinic. Appropriate modification of the molecule, did, however yield diuretic agents in man.

References

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