Acediasulfone
Acediasulfone (INN) is an antimicrobial drug, which also has antimalarial activity. It is a long-acting prodrug of dapsone, which is used for treating leprosy.
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ECHA InfoCard | 100.001.131 |
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Formula | C14H14N2O4S |
Molar mass | 306.34 g·mol−1 |
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Synthesis
Dapsone is somewhat inconvient to administer to patients because of its rather low water solubility.
In the search for more easily administered drugs, 1 was reacted with bromoacetic acid to give acediasulfone (3) which can be administered as a water-soluble salt.
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References
- Jackson EL (February 1948). "Certain N-alkyl, N-carboxyalkyl and N-hydroxyalkyl derivatives of 4,4'-diaminodiphenyl sulfone". Journal of the American Chemical Society. 70 (2): 680–4. doi:10.1021/ja01182a074. PMID 18907772.
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