ATP6V0D2

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 is a protein in humans that is encoded by the ATP6V0D2 gene. [5] It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption. [6]

ATP6V0D2
Identifiers
Aliases	ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2, ATP6D2, VMA6, ATPase H+ transporting V0 subunit d2
External IDs	OMIM: 618072 MGI: 1924415 HomoloGene: 72090 GeneCards: ATP6V0D2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.3 Start 85,987,323 bp[1] End 86,154,225 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A3 Start 19,876,841 bp[2] End 19,922,605 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • hydrogen ion transmembrane transporter activity • GO:0036442 hydrogen-exporting ATPase activity, phosphorylative mechanism • proton-transporting ATPase activity, rotational mechanism Cellular component • proton-transporting V-type ATPase, V0 domain • endosome • phagocytic vesicle membrane • membrane • apical plasma membrane • vacuolar proton-transporting V-type ATPase complex • endosome membrane • extracellular exosome • lysosomal membrane • early endosome • plasma membrane proton-transporting V-type ATPase complex Biological process • insulin receptor signaling pathway • transferrin transport • ion transport • ion transmembrane transport • regulation of macroautophagy • phagosome acidification • vacuolar transport • vacuolar acidification • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	245972	242341
Ensembl	ENSG00000147614	ENSMUSG00000028238
UniProt	Q8N8Y2	Q80SY3
RefSeq (mRNA)	NM_152565	NM_175406
RefSeq (protein)	NP_689778	NP_780615
Location (UCSC)	Chr 8: 85.99 – 86.15 Mb	Chr 4: 19.88 – 19.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000147614 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028238 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2". Retrieved 2012-11-12.
6. Wu H, Xu G, Li YP (May 2009). "Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption". Journal of Bone and Mineral Research. 24 (5): 871–85. doi:10.1359/jbmr.081239. PMC 2672205. PMID 19113919.

External links

• Human ATP6V0D2 genome location and ATP6V0D2 gene details page in the UCSC Genome Browser.

Further reading