ATP5G2

The ATP5MC2 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.[4][5]

ATP5MC2
Identifiers
Aliases	ATP5MC2, ATP5A, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9), ATP synthase membrane subunit c locus 2, ATP5G2
External IDs	OMIM: 603193 MGI: 1915192 HomoloGene: 57052 GeneCards: ATP5MC2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,632,726 bp[1] End 53,677,408 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • hydrogen ion transmembrane transporter activity • lipid binding • transporter activity • proton-transporting ATP synthase activity, rotational mechanism • GO:0001948 protein binding Cellular component • proton-transporting ATP synthase complex, coupling factor F(o) • integral component of membrane • mitochondrial outer membrane • proton-transporting two-sector ATPase complex, proton-transporting domain • mitochondrial proton-transporting ATP synthase complex • membrane • mitochondrion • mitochondrial membranes • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Biological process • ion transport • ATP biosynthetic process • ATP synthesis coupled proton transport • cristae formation • mitochondrial ATP synthesis coupled proton transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	517	67942
Ensembl	ENSG00000135390	n/a
UniProt	Q06055	P56383
RefSeq (mRNA)	NM_001002031 NM_005176 NM_001330269	NM_026468
RefSeq (protein)	NP_001002031 NP_001317198 NP_005167 NP_001356682 NP_001356683 NP_001356684 NP_001356685 NP_001356686 NP_001356687	NP_080744
Location (UCSC)	Chr 12: 53.63 – 53.68 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000135390 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Dyer MR, Walker JE (Aug 1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase". Biochem J. 293 (1): 51–64. doi:10.1042/bj2930051. PMC 1134319. PMID 8328972.
5. "Entrez Gene: ATP5MC2 ATP synthase membrane subunit c locus 2".

External links

• Human ATP5MC2 genome location and ATP5MC2 gene details page in the UCSC Genome Browser.

Further reading

• Farrell LB, Nagley P (1987). "Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex". Biochem. Biophys. Res. Commun. 144 (3): 1257–64. doi:10.1016/0006-291X(87)91446-X. PMID 2883974.
• Yan WL, Lerner TJ, Haines JL, Gusella JF (1995). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
• Houstĕk J, Andersson U, Tvrdík P, et al. (1995). "The expression of subunit c correlates with and thus may limit the biosynthesis of the mitochondrial F0F1-ATPase in brown adipose tissue". J. Biol. Chem. 270 (13): 7689–94. doi:10.1074/jbc.270.13.7689. PMID 7706317.
• Higuti T, Kawamura Y, Kuroiwa K, et al. (1993). "Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria". Biochim. Biophys. Acta. 1173 (1): 87–90. doi:10.1016/0167-4781(93)90249-D. PMID 8485160.
• Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222.
• Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.