ASTL

Astacin-like metallo-endopeptidase (M12 family) is a protein that in humans is encoded by the ASTL gene.[5]

ASTL
Identifiers
Aliases	ASTL, SAS1B, astacin-like metallo-endopeptidase (M12 family), astacin like metalloendopeptidase
External IDs	OMIM: 608860 MGI: 3046414 HomoloGene: 128191 GeneCards: ASTL
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 96,123,850 bp[1] End 96,138,436 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 127,338,639 bp[2] End 127,357,651 bp[2]
Gene ontology Molecular function • peptidase activity • glutamic-type peptidase activity • metallopeptidase activity • hydrolase activity • metalloendopeptidase activity • zinc ion binding • aspartic-type peptidase activity • metal ion binding Cellular component • cell membrane • transport vesicle • cytoplasm • membrane • cytoplasmic vesicle • cortical granule Biological process • fertilization • positive regulation of protein processing • prevention of polyspermy • proteolysis • negative regulation of binding of sperm to zona pellucida • single fertilization • cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	431705	215095
Ensembl	ENSG00000188886	ENSMUSG00000050468
UniProt	Q6HA08	Q6HA09
RefSeq (mRNA)	NM_001002036	NM_001291003 NM_172539
RefSeq (protein)	NP_001002036	NP_001277932 NP_766127
Location (UCSC)	Chr 2: 96.12 – 96.14 Mb	Chr 2: 127.34 – 127.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000188886 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050468 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Astacin-like metallo-endopeptidase (M12 family)".

External links

• Human ASTL genome location and ASTL gene details page in the UCSC Genome Browser.