ASCC3

Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.[5][6]

ASCC3
Identifiers
Aliases	ASCC3, ASC1p200, HELIC1, RNAH, activating signal cointegrator 1 complex subunit 3
External IDs	OMIM: 614217 MGI: 1925237 HomoloGene: 4973 GeneCards: ASCC3
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.3 Start 100,508,194 bp[1] End 100,881,372 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B3 Start 50,592,669 bp[2] End 50,851,485 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GO:0043140 3'-5' DNA helicase activity • GO:0001948 protein binding • hydrolase activity • ATP binding • GO:0008026 helicase activity • nucleic acid binding • RNA binding Cellular component • intracellular • membrane • nucleoplasm • cell nucleus • cytosol • activating signal cointegrator 1 complex • nuclear speck • cytoplasm • Golgi apparatus Biological process • DNA dealkylation involved in DNA repair • DNA duplex unwinding • cellular proliferation • regulation of transcription, DNA-templated • transcription, DNA-templated • cellular response to DNA damage stimulus • DNA repair Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10973	77987
Ensembl	ENSG00000112249	ENSMUSG00000038774
UniProt	Q8N3C0	E9PZJ8
RefSeq (mRNA)	NM_001284271 NM_006828 NM_022091	NM_198007
RefSeq (protein)	NP_001271200 NP_006819 NP_071374	NP_932124
Location (UCSC)	Chr 6: 100.51 – 100.88 Mb	Chr 10: 50.59 – 50.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ASCC3 has been shown to interact with RELA,[7] C-jun[7] and Serum response factor.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112249 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038774 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Coulie PG, Ikeda H, Baurain JF, Chiari R (Jun 1999). "Antitumor immunity at work in a melanoma patient". Advances in Cancer Research. 76: 213–42. doi:10.1016/S0065-230X(08)60778-2. ISBN 978-0-12-006676-6. PMID 10218103.
6. "Entrez Gene: ASCC3 activating signal cointegrator 1 complex subunit 3".
7. Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.

External links

• Human ASCC3 genome location and ASCC3 gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.