ASB6

Ankyrin repeat and SOCS box protein 6 is a protein that in humans is encoded by the ASB6 gene.[5]

ASB6
Identifiers
Aliases	ASB6, ankyrin repeat and SOCS box containing 6
External IDs	OMIM: 615051 MGI: 1919573 HomoloGene: 9895 GeneCards: ASB6
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 129,634,604 bp[1] End 129,642,169 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 30,823,097 bp[2] End 30,830,333 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • cytosol Biological process • GO:0007243 intracellular signal transduction • protein ubiquitination • post-translational modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140459	72323
Ensembl	ENSG00000148331	ENSMUSG00000039483
UniProt	Q9NWX5	Q91ZU1
RefSeq (mRNA)	NM_177999 NM_001202403 NM_017873	NM_133346
RefSeq (protein)	NP_001189332 NP_060343 NP_821066	NP_579924
Location (UCSC)	Chr 9: 129.63 – 129.64 Mb	Chr 2: 30.82 – 30.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000148331 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039483 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ASB6 ankyrin repeat and SOCS box-containing 6".

External links

• Human ASB6 genome location and ASB6 gene details page in the UCSC Genome Browser.

Further reading

• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wilcox A, Katsanakis KD, Bheda F, Pillay TS (2004). "Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex". J. Biol. Chem. 279 (37): 38881–8. doi:10.1074/jbc.M406101200. PMID 15231829.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.