ASB3

Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.[5][6]

ASB3
Identifiers
AliasesASB3, ASB-3, ankyrin repeat and SOCS box containing 3
External IDsOMIM: 605760 MGI: 1929749 HomoloGene: 9391 GeneCards: ASB3
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p16.2Start53,532,672 bp[1]
End53,860,160 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51130

65257

Ensembl

ENSG00000115239

ENSMUSG00000020305

UniProt

Q9Y575

Q9WV72

RefSeq (mRNA)

NM_145863
NM_001201965
NM_016115

NM_023906

RefSeq (protein)

NP_001157637

NP_076395

Location (UCSC)Chr 2: 53.53 – 53.86 MbChr 11: 30.89 – 31.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000115239 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020305 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chung AS, Guan YJ, Yuan ZL, Albina JE, Chin YE (May 2005). "Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II". Mol Cell Biol. 25 (11): 4716–26. doi:10.1128/MCB.25.11.4716-4726.2005. PMC 1140645. PMID 15899873.
  6. "Entrez Gene: ASB3 ankyrin repeat and SOCS box-containing 3".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.