ASB3

Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.[5][6]

ASB3
Identifiers
Aliases	ASB3, ASB-3, ankyrin repeat and SOCS box containing 3
External IDs	OMIM: 605760 MGI: 1929749 HomoloGene: 9391 GeneCards: ASB3
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.2 Start 53,532,672 bp[1] End 53,860,160 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A4|11 18.19 cM Start 30,885,416 bp[2] End 31,102,704 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • ubiquitin protein ligase binding • ubiquitin-protein transferase activity Cellular component • cytoplasm • cell nucleus • ubiquitin ligase complex • cytosol Biological process • protein ubiquitination • GO:0007243 intracellular signal transduction • post-translational modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51130	65257
Ensembl	ENSG00000115239	ENSMUSG00000020305
UniProt	Q9Y575	Q9WV72
RefSeq (mRNA)	NM_145863 NM_001201965 NM_016115	NM_023906
RefSeq (protein)	NP_001157637	NP_076395
Location (UCSC)	Chr 2: 53.53 – 53.86 Mb	Chr 11: 30.89 – 31.1 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000115239 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020305 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chung AS, Guan YJ, Yuan ZL, Albina JE, Chin YE (May 2005). "Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II". Mol Cell Biol. 25 (11): 4716–26. doi:10.1128/MCB.25.11.4716-4726.2005. PMC 1140645. PMID 15899873.
6. "Entrez Gene: ASB3 ankyrin repeat and SOCS box-containing 3".

External links

• Human ASB3 genome location and ASB3 gene details page in the UCSC Genome Browser.

Further reading

• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4". Gene. 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
• Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC 87336. PMID 11509662.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.