ASB13

Ankyrin repeat and SOCS box protein 13 is a protein that in humans is encoded by the ASB13 gene.[4][5]

ASB13
Identifiers
Aliases	ASB13, ankyrin repeat and SOCS box containing 13
External IDs	OMIM: 615055 MGI: 2145525 HomoloGene: 11666 GeneCards: ASB13
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.1 Start 5,638,867 bp[1] End 5,666,595 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytosol Biological process • protein ubiquitination • GO:0007243 intracellular signal transduction • post-translational modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79754	142688
Ensembl	ENSG00000196372	n/a
UniProt	Q8WXK3	Q8VBX0
RefSeq (mRNA)	NM_024701	NM_001267724 NM_178283
RefSeq (protein)	NP_078977	NP_001254653 NP_840068
Location (UCSC)	Chr 10: 5.64 – 5.67 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length sequences are not known.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000196372 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
5. "Entrez Gene: ASB13 ankyrin repeat and SOCS box-containing 13".

External links

• Human ASB13 genome location and ASB13 gene details page in the UCSC Genome Browser.

Further reading

• Kohroki J, Nishiyama T, Nakamura T, Masuho Y (2006). "ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes". FEBS Lett. 579 (30): 6796–802. doi:10.1016/j.febslet.2005.11.016. PMID 16325183.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.