ARIH2

ARIH2
Identifiers
Aliases	ARIH2, ARI2, TRIAD1, ariadne RBR E3 ubiquitin protein ligase 2
External IDs	OMIM: 605615 MGI: 1344361 HomoloGene: 48424 GeneCards: ARIH2
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[1]
End	108,649,386 bp[1]
Gene ontology
Molecular function	• GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • metal ion binding; • ubiquitin-protein transferase activity; • GO:0001948 protein binding; • transferase activity; • ubiquitin conjugating enzyme binding; • zinc ion binding;
Cellular component	• cytoplasm; • cell nucleus; • nucleoplasm; • Cul5-RING ubiquitin ligase complex;
Biological process	• developmental cell growth; • positive regulation of protein targeting to mitochondrion; • protein K63-linked ubiquitination; • hematopoietic stem cell proliferation; • protein polyubiquitination; • multicellular organism development; • protein K48-linked ubiquitination; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • protein ubiquitination; • ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10425
	23807
	n/a
	ENSMUSG00000064145
	O95376
	Q9Z1K6
	NM_006321; NM_001317333; NM_001317334
	NM_011790; NM_001357283; NM_001357285; NM_001357286
NP_001304262; NP_001304263; NP_006312; NP_001336138; NP_001336139;
	NP_001336140; NP_001336141; NP_001336142; NP_001336143; NP_001336144; NP_001336145; NP_001336146; NP_001336147; NP_001336148; NP_001336149; NP_001336150; NP_001336151; NP_001336152; NP_001336153; NP_001336154; NP_001336155; NP_001336156; NP_001336157; NP_001336158; NP_001336159
	NP_035920; NP_001344212; NP_001344214; NP_001344215
	Wikidata
View/Edit Human	View/Edit Mouse

Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene.[4][5]

Function

Clinical significance

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References

GRCm38: Ensembl release 89: ENSMUSG00000064145 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH (1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature". Protein Sci. 8 (7): 1557–1561. doi:10.1110/ps.8.7.1557. PMC 2144383. PMID 10422847.
"Entrez Gene: ARIH2 ariadne homolog 2 (Drosophila)".

External links

Human ARIH2 genome location and ARIH2 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics. 155 (3): 1231–1244. PMC 1461160. PMID 10880484.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–4808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197.
Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G, Menke A, de Witte T, Löwenberg B, Jansen JH, van der Reijden BA (2005). "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells". Blood. 106 (13): 4114–4123. doi:10.1182/blood-2005-04-1450. PMID 16118314.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Marteijn JA, van der Meer LT, van Emst L, van Reijmersdal S, Wissink W, de Witte T, Jansen JH, Van der Reijden BA (2007). "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1". Blood. 110 (9): 3128–3135. doi:10.1182/blood-2006-11-058602. PMID 17646546.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000064145 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10422847-4] van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH (1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature". Protein Sci. 8 (7): 1557–1561. doi:10.1110/ps.8.7.1557. PMC 2144383. PMID 10422847.

[entrez-5] "Entrez Gene: ARIH2 ariadne homolog 2 (Drosophila)".

ARIH2

Function

Clinical significance

References

External links

Further reading