ARHGEF3

Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.[5]

ARHGEF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z0Q
Identifiers
Aliases	ARHGEF3, GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3
External IDs	OMIM: 612115 MGI: 1918954 HomoloGene: 41329 GeneCards: ARHGEF3
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.3 Start 56,727,418 bp[1] End 57,079,329 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A3|14 16.09 cM Start 27,114,899 bp[2] End 27,403,911 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity • GO:0001948 protein binding • guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • intracellular Biological process • regulation of Rho protein signal transduction • GO:0007243 intracellular signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • positive regulation of apoptotic process • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50650	71704
Ensembl	ENSG00000163947	ENSMUSG00000021895
UniProt	Q9NR81	Q91X46
RefSeq (mRNA)	NM_001128615 NM_001128616 NM_001289698 NM_019555 NM_001377407 NM_001377408 NM_001377409 NM_001377410 NM_001377411 NM_001377412 NM_001377413 NM_001377414 NM_001377415	NM_001289686 NM_001289687 NM_001289688 NM_027871
RefSeq (protein)	NP_001122087 NP_001122088 NP_001276627 NP_062455 NP_001364336 NP_001364337 NP_001364338 NP_001364339 NP_001364340 NP_001364341 NP_001364342 NP_001364343 NP_001364344	NP_001276615 NP_001276616 NP_001276617 NP_082147
Location (UCSC)	Chr 3: 56.73 – 57.08 Mb	Chr 14: 27.11 – 27.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein.[5]

Interactions

ARHGEF3 has been shown to interact with RHOA[6] and RHOB.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000163947 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021895 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".
6. Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.

External links

• Human ARHGEF3 genome location and ARHGEF3 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Thiesen S, Kübart S, Ropers HH, Nothwang HG (2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem. Biophys. Res. Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2003). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.