ARHGAP8

Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene.[5][6]

ARHGAP8
Identifiers
Aliases	ARHGAP8, BPGAP1, PP610, Rho GTPase activating protein 8
External IDs	OMIM: 609405 MGI: 1920417 HomoloGene: 23645 GeneCards: ARHGAP8
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 44,752,558 bp[1] End 44,862,788 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E2 Start 84,720,052 bp[2] End 84,772,207 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cellular component • cytoplasm • cytosol Biological process • regulation of small GTPase mediated signal transduction • signal transduction • positive regulation of ERK1 and ERK2 cascade • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23779	73167
Ensembl	ENSG00000241484	ENSMUSG00000078954
UniProt	P85298	Q9CXP4
RefSeq (mRNA)	NM_181335 NM_001017526 NM_001198726	NM_001164627 NM_001164628 NM_001205334 NM_028455
RefSeq (protein)	NP_001017526 NP_001185655 NP_851852	NP_001158099 NP_001158100 NP_001192263 NP_082731
Location (UCSC)	Chr 22: 44.75 – 44.86 Mb	Chr 15: 84.72 – 84.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000241484 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078954 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. doi:10.1038/990031. PMID 10591208.
6. "Entrez Gene: ARHGAP8 Rho GTPase activating protein 8".

External links

• Human ARHGAP8 genome location and ARHGAP8 gene details page in the UCSC Genome Browser.

Further reading

• Peck J, Douglas G, Wu CH, Burbelo PD (2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274.
• Shan Z, Haaf T, Popescu NC (2003). "Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8". Gene. 303: 55–61. doi:10.1016/S0378-1119(02)01143-5. PMID 12559566.
• Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903–45914. doi:10.1074/jbc.M304514200. PMID 12944407.
• Lua BL, Low BC (2004). "BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration". Mol. Biol. Cell. 15 (6): 2873–2883. doi:10.1091/mbc.E04-02-0141. PMC 420110. PMID 15064355.
• Johnstone CN, Castellví-Bel S, Chang LM, Bessa X, Nakagawa H, Harada H, Sung RK, Piqué JM, Castells A, Rustgi AK (2004). "ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers". Gene. 336 (1): 59–71. doi:10.1016/j.gene.2004.01.025. PMID 15225876.
• Lua BL, Low BC (2005). "Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration". Biochem. Soc. Trans. 32 (Pt 6): 1110–2. doi:10.1042/BST0321110. PMID 15506981.
• Lua BL, Low BC (2005). "Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain". J. Cell Sci. 118 (Pt 12): 2707–2721. doi:10.1242/jcs.02383. PMID 15944398.